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Clinical Significance of the Changes of H₂S、NO in Serum and Cerebrospinal Fluid in Children with Different Types of Intracranial Infection

Author: HuQingPeng
Tutor: TangYongHong
School: Nanhua University
Course: Neurology
Keywords: children intracranial infection hydrogensulfide nitric oxide cerebrospinalfluid serum
CLC: R742
Type: Master's thesis
Year: 2013
Downloads: 1
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Abstract

Objective：In children with intracranial infection, through inspecting the content of H2S and NOin serum and cerebrospinal fluid, probe into the content change of H2S and NO in the threedifferent types of intracranial infection in order to detect the diagnostic method of fast andeffective to identify the different pathogens encephalitis, guide the clinical diagnosis andtreatment，improve the prognosis and reduce brain damage the greatest degree.Methods:Sixty-eight children suffered from CNSI infection whose concentration of H2S、NO inserum and cerebrospinal fluid (CSF) were determined with double antibody sandwichmethod and enzyme-linked immunosorbent assay. They included30viral encephalitis,22purulent meningitis,16tubercular meningitis, and20non-CNS disease as the controlgroup， then analyzed and compared the content of NO and H2S in CSF and serum withthe non intracranial infection and intracranial infection children group, and compared thelevels of NO and H2S in serum and CSF in order to probe the changes and interaction ofNO and H2S in different types of intracranial infection children and look for the rapiddetection of diagnostic method to identify the different intracranial infection. Results wereanalyzed by SPSS20.0. There was statistical difference when P<0.05.Results:1. With intracranial infection children,the levels of H2S in the cerebrospinal fluid wereperformed and purulent meningitis was the highest, followed by tuberculous meningitis group, viral encephalitis group was the lowest, the data are as follows:①Purulentmeningitis group was46.4±7.4μmol/L, P=0.001compared with the control group;②Tuberculous meningitis group was33.6±5.7μmol/L, P=0.003compared with thecontrol group;③Viral encephalitis group was13.3±2.2μmol/L, compared with controlgroup, P>0.05; the tuberculous meningitis and purulent meningitis group were obviouslyhigher than the control group10.8±2.4μmol/L; However,there is no obvious difference inviral encephalitis group, and the differences in each intracranial infection group were alsosignificant.2. With intracranial infection children,the levels of NO in the cerebrospinal fluid wereperformed and tuberculous meningitis group was the highest, followed by purulentmeningitis group, viral encephalitis group was the lowest, the data are as follows:①Tuberculous meningitis group was105.3±9.7μmol/L,P=0.001compared with the controlgroup;②P urulent meningitis group was97.3±10.7μ mol/L,P=0.002compared with thecontrol group;③Viral encephalitis group was86.2±5.8μmol/L,P=0.005compared with thecontrol group;significantly higher than that of control group35.9±5.4μmol/L group, andthe differences in each group were also significant.3. With intracranial infection children,the levels of H2S in serum were performed andpurulent meningitis was the highest, followed by tuberculous meningitis group, viralencephalitis group was the lowest, the data are as follows:①Purulent meningitis groupwas89.4±6.5μmol/L,P=0.001compared with the control group;②Tuberculous meningitisgroup was83.3±6.8μmol/L.P=0.005compared with the control group;③Viralencephalitis group was34.5±5.3μmol/L, P>0.05compared with the control group, thetuberculous meningitis and purulent meningitis group were obviously higher than the viralencephalitis group; and there is no obvious difference in viral encephalitis group.4. With intracranial infection children,the levels of NO in serum were performed andtuberculous meningitis group was the highest, followed by purulent meningitis group, viral encephalitis group was the lowest, the data are as follows:①Tuberculous meningitisgroup was76.2±7.7μmol/L, P=0.001compared with the control group;②Purulentmeningitis group was63.3±5.1μmol/L P=0.002compared with the control group;③Viralencephalitis group was45.7±5.3μmol/L, P=0.005compared with the control group;significantly higher than that of control group21.8±5.2μmol/L, and the differences in eachgroup were also significant.Conclusions:1. With intracranial infection children, the levels of H2S and NO increased incerebrospinal fluid and serum, suggesting that endogenous H2S and NO were involved inthe pathogenesis and development of intracranial infection.2. With intracranial infection children, the levels of H2S and NO have a significantdifference in CSF and serum, indicated the detection of NO and H2S was meaningful in thedifferential diagnosis and diagnosis with different types of intracranial infection.

Clinical Significance of the Changes of H2S、NO in Serum and Cerebrospinal Fluid in Children with Different Types of Intracranial Infection

Abstract

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Clinical Significance of the Changes of H₂S、NO in Serum and Cerebrospinal Fluid in Children with Different Types of Intracranial Infection