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Objective: gestational metabolic syndrome (GMS) by pregnant women of the metabolic syndrome (MS) analysis of pre-eclampsia (PE) phenotype to explore the mechanisms of the association between preeclampsia and metabolic syndrome; evaluation methods. Methods: A cross-sectional study, 178 cases for the study group selected hospital delivery in the Maternal and Child Health Hospital of Guangdong Province in September 2009 -2011 in March preeclampsia pregnant women, the same period in the hospital delivery have regular check-ups during pregnancy normal pregnant women, 253 cases pregnant times for the control group, two groups of pregnant women, gestational age, age comparison, the difference was not statistically significance (P gt; 0.05). All of the subjects were collected measuring fasting blood total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), free fatty acid (FFA), fasting plasma glucose (FPG) and fasting insulin (Fins), calculation of pre-pregnancy body mass index (BMI), insulin resistance index (HOMA-IR). Preeclampsia pregnant women, regardless of size of gestational age, once the confirmed line OGTT test. Compare the two groups anthropometric parameters, parameters of glucose metabolism, lipid metabolism parameters. Reference to the definition of the 2004 Chinese Medical Association Diabetes metabolic syndrome work, combined with gestational physiological metabolic changes, evaluation of the metabolic syndrome in pregnancy, metabolic syndrome phenotype analysis of incidence in each group. Statistical Methods SPSS13.0 software package, two sets of metabolic indicators compared with t test and correlation analysis using Spearman correlation analysis; compared by chi-square test. Results: 1. Compared with the control group, pre-eclampsia (PE) group of pregnant women have a higher pre-pregnancy body mass index (BMI) (23.26 ± 2.58 vs 21.95 ± 3.12, P lt; O.01), FPG (4.66 ± 0.90 mmol / L vs 4.31 ± 0.55 mmol / L, P = 0.012), HOMA-IR (2.32 ± 1.25 vs 1.95 ± 1.15, P = 0.015), TG (4.38 ± 1.57 mmol / L vs 2.92 ± 1.09 mmol / L, P = 0.015), FFA (776.12 ± 209.96 mmol / L vs 530.35 ± 273.39 mmol / L, P = 0.000) and TC (5.91 ± 1.42 mmol / L vs 5.60 ± 0.91 mmol / L, P = 0.000). Pre-pregnancy BMI, FFA, TG, TC, FPG and HOMA-IR was significantly related, r, respectively: 0.158,0.217, 0.195, 0.082, 0.137, P lt; 0.05 3. According to the Diabetes Society of the Chinese Medical Association in 2004 metabolism syndrome working definition, the combined physiological metabolic changes during pregnancy, the of gestational metabolic syndrome (GMS) evaluation, that have the following three or all of the persons diagnosed as the GMS: ① overweight and (or) Obesity: pre-pregnancy body mass index ( BMI) ≥ 25; ② meet the the pregnant diabetic diagnostic criteria and (or) insulin resistance (of HOMA-IR ≥ same gestational age mean 2SD): the ③ hypertension: blood pressure ≥ 140/90 mm Hg; ④ dyslipidemia: fasting TG ≥ same Mean 2SD of gestational age and (or) fasting plasma HDL-C ≤ same gestational age mean-2SD. According to the preliminary evaluation criteria for the metabolic syndrome during pregnancy, the incidence of MS phenotype in the PE group is higher than that in control group: overweight or obese: 29.78% vs 11.46%, P lt; 0.001; hypertension: 100% vs 0, P lt; 0.001; abnormal glucose metabolism: 25.25% vs 0, P lt; 0.001; Insulin resistance: 32.58% vs 10.46%, P lt; 0.001), high TG: 38.20% vs 9.80%, P lt; 0.001. According to our proposed late pregnancy, metabolic syndrome of the evaluation criteria, 32.02% PE pregnant women may be diagnosed as metabolic syndrome. Conclusion: 1. Compared with normal pregnancy, PE pregnant women there are more obvious pre-pregnancy obesity, insulin resistance, abnormal glucose metabolism and lipid metabolism abnormality. Part of PE pregnant women with obesity, high blood pressure, high cholesterol, insulin resistance, high blood sugar and other metabolic syndrome phenotype. The general population of the metabolic syndrome diagnostic criteria do not apply to pregnant women, it is necessary to develop the evaluation criteria of the metabolic syndrome during pregnancy according to the characteristics of metabolic changes during pregnancy. 4. Evaluation method, based on the recommendations of gestational metabolic syndrome and about 30% PE women with metabolic syndrome in pregnancy. 5 The study confirmed PE with MS for PE prevention, treatment, and follow-up to provide new ideas: a planned pregnancy or pregnant women, a good diet and lifestyle guidance, control weight and blood sugar, actively lipid lowering therapy, reduce insulin resistance, reduce the incidence of preeclampsia, ensure maternal and child health, prenatal and postnatal care and blocking pregnant women, long-term metabolic syndrome, cardiovascular disease, and the incidence of type 2 diabetes is important. Further in-depth study of the metabolic indicators of pregnancy, may provide a new theoretical basis for the prevention and treatment of pre-eclampsia.
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