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The Effect of Jianpi Yiqi Qingyou Decoction on Lymphocyte Subsets and IL-2 in Rats with Chronic Superficial Gastritis

Author: HuYongMin
Tutor: JiangWei
School: Guilin Medical College,
Course: Department of Gastroenterology,
Keywords: The spleen qi quiet soup Chronic superficial gastritis Lymphocyte subsets IL-2
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 13
Quote: 0
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Abstract


Objective To explore the spleen qi quiet soup chronic superficial gastritis, gastric tissue in rats lymphocyte subsets and of IL-2mRNA and serum IL-2. 66 Wistar rats were randomly divided into blank control group, model group, treatment group (TCM small dose group, dose group of traditional Chinese medicine, Chinese medicine big dose group) and lansoprazole group, in addition to the normal group, 11 of the remaining large mice to 0.02% ammonia free drink with hunger and satiety alternating method (d sufficient food, 1 d fasting) feed for 90 consecutive days, the preparation of rats with experimental the superficial gastritis animal model. With the HE staining Animal modeling success. Quiet soup Jianpiyiqi gavage treatment of rats for 30 days, orally once a day, after the end of treatment, anesthesia killed Immunohistochemical detection of gastric tissue CD 3 , CD 4 and the CD of 8 T cells, detected by RT-PCR in gastric tissue IL-2mRNA expression with measured by radioimmunoassay in serum IL-2 levels. Results Spleen Qi quiet soup high-dose group, middle dose group and lansoprazole group rat gastric tissue CD 3 T, CD 4 T-cell count was significantly higher the the CD 8 / sub> . T cell numbers decreased significantly compared with the model group, there were significant differences (P lt; 0.01 or P LT; 0.05). High-dose group, middle dose group and lansoprazole group rat gastric tissue IL-2mRNA expression was significantly increased compared with the model group, a significant difference (P lt; 0.01); Chinese medicine high-dose group, middle dose group and Lansuo omeprazole serum IL-2 were significantly elevated compared with the model group, a significant difference (P lt; 0.05). Conclusion (1) chronic superficial gastritis in rats weakened immune function, gastric mucosal the the CD 4 / CD 8 ratio imbalance, CD 3 for CD 4 decrease in T cell numbers the the CD 8 / sub> . T cell count increased, serum IL-2 decrease in the number of, stomach tissue of IL-2mRNA the decreased expression. (2) the treatment of the the spleen qi quiet soup, chronic superficial gastritis rat gastric mucosa CD 4 / CD 8 ratio increased to the CD 3 < / sub> , the CD 4 T cell count increased, CD 8 T cells The decline in the number. Help improve immune function in rats in varying degrees, and Chinese medicine high-dose group immune function improve significantly, suggesting that this prescription of chronic superficial gastritis significant therapeutic effect. (3) the treatment of the the spleen qi quiet soup, chronic superficial gastritis rat gastric tissue IL-2mRNA expression significantly increased serum IL-2 were significantly increased, suggesting that the cellular immune function in rats have improved to varying degrees this prescription significant role in the treatment of chronic superficial gastritis. (4) The mechanism for the treatment of chronic superficial gastritis Jianpiyiqi quiet soup: the Spleen Qi quiet Soup correct the gastric mucosa CD 4 / the the CD 8 ratio and and Th1/Th2 CD between the 4 / sub> . T cells and CD 8 T cells, Th1 and Th2 achieve a balance between restoration of normal immune function.

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