Dissertation > Excellent graduate degree dissertation topics show

Association between Polycyclic Aromatic Hydrocarbons and Human Rectal Tumor

Author: CongLiYuan
Tutor: LunLiMin
School: Qingdao University
Course: Clinical Laboratory Science
Keywords: rectal cancer Polycyclic aromatic hydrocarbons high performance liquid chromatography
CLC: R735.37
Type: Master's thesis
Year: 2011
Downloads: 13
Quote: 0
Read: Download Dissertation

Abstract


Objective:To investigate if there were polycyclic aromatic hydrocarbons (PAHs) in human rectum; To evaluate the difference of the contents of the PAHs between rectal tumor and normal rectum; And to investigate the effect of PAHs in the occurrence of human rectal tumor.Methods:PAHs in human rectal tumor, adjacent tissues and normal rectum were extracted by ultrasonic wave. And then the extracts were cleaned up by solid phase extraction and analyzed by high performance liquid chromatography with fluorescence detector.Results:Four kinds of PAHs were detected, which were phenanthrene, pyrene, 2-methylanthracene and benzo (a) pyrene. The content of benzo (a) pyrene in rectal tumor was more than other PAHs, which was (1129.3±333.9) ng/g; The contents of pyrene, 2-methylanthracene and benzo (a) pyrene in both rectal tumor and adjacent tissues were higher than normal rectum, the differences were statistically significant (P<0.05). The contents of phenanthrene in the three kinds of tissues were not statistically significant (P>0.05). The contents of the four PAHs were not statistically significant between rectal tumor and adjacent tissues (P>0.05).Conclusion:(1) It is the first reported that PAHs were found in human rectal tissue. (2) Human rectal tissue has extremely strong ability of bioconcentrating PAHs. (3) The contents of PAHs in rectal tumor are higher than normal rectum, the differences were statistically significant (P<0.05). (4) The contents of PAHs and the occurrence of human rectal tumor may have a certain correlation.

Related Dissertations

  1. Synthesis and Resolution Property of N-(9-Fluorenylmethoxycarbonyl)-D-Tryptophan and D-Phenylalanine Imprinted Polymer,O631.3
  2. The Study on Rhinoceros Horn and Its Imitation,TS932.2
  3. Research on Melamineanalysis Method in Milk Powder and Establish the System of Rapid Determination,O657.3
  4. Fast Determination Method Research of Bisphenol A in Food Packing Material,TS206.4
  5. Analysing Sequence Characters of ADSL and PurH Gene and Correlation between Genes Expression and IMP Content in Duck,S834
  6. A Role of Auxin in Repression of Harpin-Induced Hypersensitive Response in Tobacco,S432.1
  7. Study on Synthesis of Polysaccharide Tris (Phenylcarbamates) Derivatives as Chiral Stationary Phases (CSPs) and Estimation of Their Resolution Abilities,TQ460.1
  8. Synthesis and Quality Control Research of ATPR,TQ463
  9. Research on Free Amino Acids Analysis Techniques of Flue-cured Tobacco and Application,S572
  10. Phenylenediamine in hair dye substances and several separation and analysis of trace heavy metals Determination Method,TQ658.34
  11. The Comparative Study of Two Deproteinized Methods on Xenogeneic Bone Graft Substitute Material,R687.3
  12. The Soxhlet Extraction, Separation and Adsorption Performance of Polyaromatic Hydrocarbons from Shenmu Coal,TK16
  13. Study on Gas/Particle Phase Distribution of Polycyclic Aromatic Hydrocarbons During Diesel Combustion with PTV Method,TK421.5
  14. Study on the Application of Cloud Point Extraction in Speciation Analysis of Heavy Metal Ions,X830.2
  15. Effects of DOC And/or POC on the Exhaust Emissions from Diesel Engine,TK421.5
  16. Effects of Enzymes on Metabolism of Polycyclic Aromatic Hydrocarbons in Plant,X173
  17. Study on Tissue Distribution of Lyophilized 2-methoxyestradiol Liposome in Rats,R96
  18. Preparation of Poly(Vinyl Ester Resin) Monolith and Its Application to the Analysis of Drug in Plasma,R917
  19. Construction of Analytical Platform for Tryptophan Biosynthesis Metabonomics Based on the LC-MS/MS,R96
  20. Chiral Resolution Applied Research of Four Racemic Pesticides on CHIRALPAK AS-H Chiral Column by High Performance Liquid Chromatography,S48
  21. The Analysis of Process Flavoring and Basic Research on Standard’s Establishment,TS202.3

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Rectal cancer
© 2012 www.DissertationTopic.Net  Mobile