Dissertation > Excellent graduate degree dissertation topics show

Design of Magnetic Nanoparticles Immunoassay System

Author: DuZhongZhou
Tutor: KongLi; LiuWenZhong
School: Huazhong University of Science and Technology
Course: Detection Technology and Automation
Keywords: magnetic nanoparticles immunoassay digital phase-sensitive detection constanttemperature control detection coil
CLC: TP274
Type: Master's thesis
Year: 2012
Downloads: 13
Quote: 0
Read: Download Dissertation

Abstract


This thesis applies the linear relation between the magnetization of magneticnanoparticles and their concentration, in accordance with the Langevin equation, to researchinto the magnetic nanoparticles application in immunoassay field. Preliminary designing asimple measurement system is aiming to experimentally verify the feasibility of the theory ofmeasuring the concentration. This measurement method has a broad application prospect inmany fields, especially in biomedicine, such as the tumor hyperthermia and the nanoparticletemperature imaging.Based on the Langevin equation, this thesis applies the linear relation between themagnetization of magnetic nanoparticles and their concentration, and the imagingreconstruction model of Bernhard Gleich and Jurgen Weizennecker, to form theconcentration imaging. This thesis elaborates the deduction of the measurement thoery.Because the concentration of magnetic nanoparticles is very sensitive to the temperature, theconcentration varies with the ambient temperature. Theoretical deduction of this point isgiven in chapter two. So in the design of the measurement system, the constant temperaturesystem must be considered.Considering the principles of the measurement and comparingdifferent measurements of week magnetization, this thesis chooses a better measurementmethod. And through the experiment test using the lock-in amplifier of the Agilent Company,the feasibility of the method is simply proved. An immunoassay system based on themagnetic nanoparticles is designed.A signal detection soft system is designed based on the data acquisition card of the NICompany. A constant temperature system is designed using the temperature transmitter andthe platinum resistance transducers of the Siemens. The precision of the controlledtemperature is plus or minus0.1Kelvin.

Related Dissertations

  1. The Precise Measurement on Anti-HBc and Anti-HBe Detected by Chemiluminescent Microparticle Immunoassay,R512.6
  2. Complex functions drug-loaded microspheres and in spinal cord injury treatment Application of,R943
  3. Cyclodextrin -modified magnetic nanoparticles synthesis and study drug carrier,TQ460.1
  4. Studies on Magnetic Nanocomposite Particles as Drug Carriers for Photodynamic Therapy Agents,TB383.1
  5. Construction of Multi-responsive Gene Vector Via Layer-by-Layer Assembly,TB383.1
  6. Fabrications and Applications of Microelectrode Array of Silicon Dioxide Cavities and Magnetic Ferroferric Oxide Nano-Bioconjunctions,TB383.1
  7. Detection of Avidin from Egg White Based on Magnetic Nanoparticles,TS253.1
  8. Surface-enhanced Raman Spectroscopy Based Magnetic Separation and Immunoassay,R318.51
  9. Multifunctional Magnetic Nanoparticles Used for EPR Bio-probes,TB383.1
  10. Development of Magnetic Microbead-based Enzyme Immunoassay for Detection of Schistosoma Japonicum Antibody in Human Serum,R446.6
  11. Study of Immobilized Enzyme Based on Magnetic Nanoparticles,Q814.2
  12. Multi-channel Data Acquisition System for 3D Induction Logging Tool,P631.83
  13. The Construction of Streptavidin-Fluorescence Phycobiliprotein(SA-CpcB-PEB) and Its Application to Fluorescence Immunoassay,O657.3
  14. Safety Detection Technology of Agricultural Products Based on the Peroxidase-like Activity of Magnetic Nanoparticals,S13
  15. Induction of Bitches Estrus and Detection of Reproductive Hormones in Bitches during Estrus,S829.2
  16. Antigen Design for Deoxynivalenol and the Direct Competitive Enzyme-linked Immunosorbent Assay,R392.1
  17. Application of Biofunctionalized Nanoparticles for Detection of Escherichia Coli O157:H7,R155
  18. CdTe Quantum Dot Based Detection Method for Pathogenic Bacteria and Macrophages,TS207.4
  19. Novel Luminescent Nanomaterials Labeling Based Detection Method for Salmonella,TB383
  20. Development and Application of Tumor-targeting Magetic Nanoparticles for Hyperthemia,TB383.1
  21. Developing of a Novel Clinical Kit for Assaying of Alpha-Fetoprotein Based on Luminescing and Magnetic Nano-Materials,TB383.1

CLC: > Industrial Technology > Automation technology,computer technology > Automation technology and equipment > Automation systems > Data processing, data processing system
© 2012 www.DissertationTopic.Net  Mobile