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The Role of Magnetic Nanoparticles Loaded Doxorubicin and Verapamil in Reversing MDR Phenotype of Gastric Cancer

Author: YangHeng
Tutor: YangQiang
School: Chongqing Medical University
Course: Surgery
Keywords: magnetic nanoparticles MDR gastric cancer apoptosis
CLC: R735.2
Type: Master's thesis
Year: 2013
Downloads: 47
Quote: 0
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Abstract


Objective：Through the comparison for the similarities and differencesof three nanoparticles-magnetic nanoparticles loaded verapamil anddoxorubicin, magnetic nanoparticles loaded doxorubicin alone and magneticnanoparticles loaded verapamil alone, analysis the effect of reversingmultidrug resistance（MDR） in gastric cancer cells. Methods：synthesizethe magnetic nanoparticles in heating curing method, characterize thesemagnetic nanoparticles in scanning electron microscopy (sem), invertedmicroscope and spectrophotometer, analysis the effect of reversing MDR inCCK-8and western blot experiment. Result：magnetic nanoparticles is theaverage diameter of250nm with good dispersibility and magneticresponsiveness, magnetic nanoparticles have cytotoxic effect onmulti-resistant cells, down-regulating the expression of Bcl-2andup-regulating the expression of Bax. Conclusion：magnetic nanoparticlescan reverse MDR in gastric cancer cells, the mechanism may be restrainingthe function of p-gp, activating apoptosis pathways.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
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