Dissertation > Excellent graduate degree dissertation topics show

Investigation on Methodology for the Synthesis of Nitrogen Heterocycles

Author: DongChunPing
Tutor: SunXiaoQiang
School: Changzhou University
Course: Chemical processes
Keywords: nitrogen heterocycles N-OH-1,4-dihydropyridines diazabicyclo azetidines azetines
CLC: O626
Type: Master's thesis
Year: 2013
Downloads: 20
Quote: 0
Read: Download Dissertation


Nitrogenous heterocyclic compounds play an important role inheterocyclic compounds, many chemists are enthusiastic about researchingthem due to their unique biological activity.1,4-Dihydropyridines are a kindof important calcium channel blockers and widely used in the treatment ofhypertension, angina pectoris, arrhythmia and other cardiovascular diseases.Nitrogenous four-membered ring compounds have special antibacterialactivity and play an important role in many conversion reaction due to theirspecial constrained structure. In addition, they also can be used as theintermediates to synthetize many amino acids, alkaloids and other natural orunnatural biological macromolecular compounds. Therefore, it is significantto study the novel synthetic methods of1,4-Dihydropyridines and nitrogenousfour-membered ring compounds. In this dissertation, our work is aboutdeveloping novel synthethic methodologies, which can be specialized as thefollowing:1. One-pot synthesis of4-aryl-N-OH-Hantzsch estersA mild and convenient one-pot method for the synthesis ofN-OH-Hantzsch esters was developed. The key step is controlling the firstMichael addition at relatively lower temperature (0oC) to prevent the furthercyclization. To optimize the addition reactions for better yield, varioussolvents and bases were screened. Symmetrical and unsymmetricalN-OH-Hantzsch esters can be easily obtained in moderate yield using thismethodology. Furthermore, the terminal hydroxyl group makesN-OH-Hantzsch esters be further transformed or introduced to other moleculeeasily for further investigation of the potential use in medicinal fields. Themethodology is considered to be simple, gentle and with low cost.2. Study on the stereoselective synthesis of1,3-diazabicyclo heptanesand heptenes in the presence of iodineWe studied the one-pot preparation of1,3-diazabicyclo heptanes andheptenes with high stereoselectivities from substituted amino diethylmalonates and chalcones mediated by I2and base. The influence of the base,solvent and reaction temperature on those reactions was investigated in detail. We also explored an efficient method to construct imidazolidine derivativeswith high yield and diastereoselectivity. Moreover, we studied investigatedthe ring-opening reaction of1,3-diazabicyclo heptanes with differentnucleophilic reagents. The advantages such as being mild and simple, lowcost, the high chemoselectivity and wide range of applications make thecurrent method very attractive and appealing.

Related Dissertations

  1. Study of Synthesis of Nitrogen Heterocycle Compounds as Antiviral Drugs,TQ463.5
  2. Synthesis and Characterization of Hexahydropyrimidine Derivatives and 1, 5-Diazabicyclo-Compounds,O626.41
  3. Study on the Synthesis and Crystallization Process of 1,4-diazabicyclo(2.2.2)octane,O626
  4. Study on Synthesis of Key Intermediate of Moxifloxacin,TQ463
  5. Research on the Synthesis, Optical Properties and Application of a Novel Class of Fluorescent Pentasubstituted Tetrahydropyrimidines,O626.41
  6. Study on Pd(Ⅱ) Catalyzed Oxidative Domino Cyclization Reactions under Aerobic Condition and Palladium-catalyzed Coupling Reaction of Sonogashira,O643.32
  7. Experimental Study on Absorption of CO2Using DBU Solution in a Bubbling Bed,X701
  8. Performance and Mechanism Research on CO2Adsorbent of DBU Loaded on GAC,X701
  9. Preparation,Characterization and CO2Adsorption Performance of Al2O3Supported DBU,X701
  10. Pd-Catalyzed Synthesis of N-substituted Pyridin-1(2H)-one Derivatives,O626.32
  11. The Study of Multicomponent Reactions of Benzimidazolium Salts and Phenanthrolinium Salts,O621.25
  12. Studies on the Synthesis, Biological Activities and Thermodynamic Properties of the Pyrimidine and Triazole Compounds Containing Nitrogen Heterocycles,O626.2
  13. Synthesis of Benzimidazolium Ionic Liquids and Their Application in Extraction Separation,O626.23
  14. Synthesis, Luminescent Properties of Pyrazoline and Carbazole Compounds,O626.2
  15. Synthesis and Photochromic Caused by Visible Light of Conjugated Thiophene Spirooxazine Compounds,O626.12
  16. Diastereoselective Synthsis of β-amido Acetals and Dihydroxazine Derivatives from the Additional Reaction of N,O-acetals with Electron-rich Olefins,O626.3
  17. Synthesis and Characterization of Conjugated Polymers,O626
  18. Studies on the Synthesis of Imidazole, Oxazole and Quinoxaline,O626
  19. Synthesis of Novel Heterocyclic Receptors and the Recognition Properties,O626
  20. Benzene and furyl 1,2,4 - triazole and 1,3,4 - oxadiazole Derivatives,O626.2
  21. Preparation and Characterization on Ionic Liquid 1-Buty-3-Methylimidazolium Hexafluorophosphate and the New Anhydrous Conducting Membranes Based on Polymers of Sulfonated Poly (Ether Ether) Ketone and Polyvinylidenefluoride,O626.23

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds
© 2012 www.DissertationTopic.Net  Mobile