Dissertation > Excellent graduate degree dissertation topics show

Peptidic Dendronized Polyisocyanides

Author: HuYuLong
Tutor: ZhangAFang
School: Shanghai University
Course: Organic Chemistry
Keywords: Polyisocyanides Helical polymers Dendonized polymers Dynamicbond Chiral transfer Peptides
CLC: O632.62
Type: Master's thesis
Year: 2013
Downloads: 1
Quote: 0
Read: Download Dissertation

Abstract


With comparable size to the biological macromolecules, helical dendronizedpolymers will not only offer the possibilities to directly visualize thesemacromolecules and to investigate the relationship between their chemical structuresand helical conformations, but also provide chiral environments on an individualmolecule level, which may have promising applications in various areas. Therefore,investigation of macro-size helical polymers is of great significance in the field offundamental research and material applications.Helical polyisocyanides stand out among various helical polymers due to theirhigh dense pendants and highly rigid backbones. In present thesis, we firstlydesigned and prepared series of aliphatic and aromatic polyisocyanides carryingpeptide-based chiral dendrons by grafting through method. It was found that thegrafting through method only afforded oligomers due to the large steric hindranceof the side lysine dendrons. To obtain macro-size dendronized polyisocyanides withhigh molecular weights, dynamic hydrazone bond was used to link the backbone ofpolyisocyanide and the side glutamic acid-based dendron. CD spectroscopy wasutilized to investigate the relationship between the structure and conformation of thedendronized polyisocyanides. The results show that the length, rigidity andconformation of the linkage spacer have important effects on the chiral transfer.

Related Dissertations

  1. Effect of β-Casomorphin7 or Casein Peptides on Blood Glucose and Oxidative Stress of the Diabetic Rats,R587.1
  2. Study on Extraction of Chlorogenic Acid and Preparation of Functional Peptides from Sunflower Seeds,TS255.1
  3. Study on Preparation Isolated Proteins and Active Peptides from Pumpkin Seeds,TS201.21
  4. Bioactive peptides capsules Analysis and Application,R927.2
  5. Synthesis of Ziconotide by Solid Phase Method Via Selective Oxidation,TQ463
  6. Screening of Specific Antibody Binding Peptides and Applied Research in Serology Detection of Mycobacterium Tuberculosis,R52
  7. Isolation, Purification and Quantitative Structure Activity Relationship of ACE Inhibitory Activity Peptides from Grass Carp Protein,TQ464.7
  8. Study on Producing Rapeseed Acei Peptides by Liquid-State Fermentation,TS229
  9. Preparation of Angiotensin Ⅰ Converting Enzyme Inhibitory Peptides and Antioxidant Peptides from Shrimp Shell Protein,TS254.9
  10. The Development of Perilla Protein Products;the Development of Perilla Protein Products,TQ936.2
  11. Skimmed milk powder small and medium- peptide content with the functional activity research,TS252.7
  12. A Study on Production of Antioxidative Whey Peptides in Tangential Flow Filter Enzymatic Membrane Reactor,TS201.2
  13. Preparation and Purification of Soybeam Peptides with Anti-oxidant Activity,TQ464.7
  14. Study on Preparation Oface Inhibitory Peptides and Antioxidative Peptides from Oat Protein by Enzymatic Membrane Reactor,TQ464.7
  15. Study on Physiological Effects Induced by Chemical Substance on Cold Resistance in Banana Seedlings,S668.1
  16. Effect of Low Protein Diets Adding Small Peptide on the Performance and Immunity Index in Growing Pigs,S828.5
  17. Inhibitary Effect of Liposomes Modified by NGR Peptide for PEI-antisense Oligodeoxynucleotide of hTERT on Growth of Breast Tumor Transplanted Subcutaneously in Nude Mice,R737.9
  18. The Interaction between Copper Ions and Different Aggregated Forms of Aβ in Alzheimer’s Disease,R749.16
  19. Enhancement of TAT Cell Membrane Penetration Efficiency by Dimethyl Sulphoxide (DMSO),R363
  20. Study on Hepatoprotective Effects and Struture of Ganoderma Lucidum Peptides,R285.5
  21. Tandem Expression of LNK-16 Like Bovine Antimicrobial Peptide in E.coli,Q78

CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Carbon - chain polymers > Nitrogen compounds in polymer > Nitrile polymer
© 2012 www.DissertationTopic.Net  Mobile