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Study of QCM Gas-and Bio-Sensors with Sensing/Enhancing Nanomaterials

Author: DingPengFei
Tutor: LiGuang
School: Zhejiang University
Course: Control Science and Engineering
Keywords: Quartz crystal microbalance Gas Sensors Immune Sensors Nano- polyaniline Gold nanoparticles Dibutyl phthalate Microalbumin C- reactive protein
CLC: TP212.3
Type: PhD thesis
Year: 2014
Downloads: 13
Quote: 0
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Abstract


Quartz crystal microbalance (Quartz Crystal Mircrobalance, QCM) is a sensor for measuring technology of piezoelectric effect of quartz crystal based on the electrode surface quality were measured. It converts the micro mass change of crystal surface for the change in resonant frequency of quartz crystal, and inspect the nanogram level, is a very sensitive quality testing instruments, has the advantages of simple structure, low cost, high sensitivity, highly digitized, easy to real-time online detection etc.. This project has focused on QCM chemical / biosensor and its application in gas detection and biochemical analysis of two areas, combined with nano material, detection are realized. The gas phase specific gas molecules, immunological specificity and liquid environment biochemical substances, and has very high application value and wide market future. In this paper, the technology of gas sensor sensitivity, biological sensing technology is summarized and analyzed. From the two aspects of gas sensitive materials and analysis methods of the sensitive mechanism and characteristics of various gas sensors; from the two aspects of biological immobilization methods and immunoassay method to analyze the working principle and characteristics of various types of biological sensors. To elaborate the theoretical basis of QCM quality effect, the structure of QCM and equivalent circuit theory. And introduced the research progress and application of QCM sensor in the gas sensor and the immune sensor. At present, dibutyl phthalate (DBP) gas detection equipment is bulky, expensive, complex operation shortcomings, the research of the QCM gas sensor of polyaniline nanofibers modified for trace gas detection of DBP. The preparation of polyaniline nanofibers prepared by ultrasonic polymerization of polyaniline nanofibers, the solution is applied to a QCM electrode of QCM gas sensor, the sensitivity, response of gas sensor for DBP gas response time, reproducibility, selectivity, and long time stability; and through the comparative analysis of the improvement effect of QCM gas sensor sensing properties of modified by nano materials. The research of QCM immune sensor double antibody sandwich method effect of nano gold particles based on enhanced for the detection of albumin and C- reactive protein. Experiment using immobilized on SAMs technology will antibody immobilized on the QCM gold electrode surface preparation of immune sensor, under the condition of liquid phase by flow injection mode to complete the specific detection of protein, and the introduction of nano gold particles reinforced effect, formation was detected by double antibody sandwich method, further amplification of antigen antibody binding reaction with fixed signal the detection sensitivity is improved.

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CLC: > Industrial Technology > Automation technology,computer technology > Automation technology and equipment > Automation components,parts > Transmitter ( converter),the sensor > Biological sensors,medical sensors
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