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Objective: To investigate the type and clinical features of patients with obsessive-compulsive disorder symptom clusters, provides a screening method of the homogeneity of the sample, symptomatology basis for clinical diagnosis and treatment. To investigate the quality of life for patients with obsessive-compulsive disorder and its influencing factors to further compare the different symptom clusters in patients with obsessive-compulsive disorder quality of life, provide entry points to improve the patient's quality of life and some scientific basis. Methods: 78 outpatients with obsessive-compulsive disorder patients and 60 normal subjects as the control group. Yale - Brown Obsessive Compulsive Scale Symptom Check outline (Y-BOCS-SC) of patients with obsessive-compulsive symptoms score, the score results of the factor analysis, access to the group of obsessive-compulsive symptoms typing. And then compare the different symptom clusters in patients with clinical characteristics, such as age, years of education, the first onset age, duration, Yale - Brown Obsessive Compulsive Scale total score. World Health Organization Quality of Life Short Form (WHOQOL-BREF) to assess the quality of life of the patient group and the normal group, and the results were analyzed. Further analysis of the factors affecting the quality of life of patients with obsessive-compulsive disorder. Finally, differences in the quality of life for different symptom clusters in patients with obsessive-compulsive disorder. Results: (1) factor analysis show that four obsessive-compulsive symptoms group (cumulative contribution rate of 74.7%), washing, inspection, storage and symmetrical. The main symptoms are divided into washing group, the inspection team, the storage group, the symmetry group according to the patient as to which type of symptom clusters. Four groups of patients with years of education, age of onset for the first time, Yale - Brown Obsessive Compulsive Scale total score and insight score differences (F values ??were 4.35,4.06,3.71,3.16), the difference was statistically significant (P values ??are less than 0.05). (2) The case group WHOQOL-BREF areas physiological, psychological field, the field of social relations, the field of the environment score (64.7 ± 10.3) min (47.6 ± 11.5) (53.1 ± 12.2), (63.7 ± 10.6 -8.3, -12.5, -10.9, -6.3, P less than 0.0001). Multiple regression analysis showed obsessions, compulsive behavior, associated with depressive symptoms is an important factor of the quality of life in patients with obsessive-compulsive disorder. (3) analysis of variance showed 4 groups of patients WHOQOL-BREF areas physiological, psychological field, the field of social relations, the field of the environment score differences (F values ??were 5.35,6.38,5.89,3.76), the difference was statistically significant (P value less than 0.05). Conclusion: (1) This research has analyzed four forced symptom clusters, namely, washing, inspection, storage and symmetry, consistent with the findings of Western and Asian countries, which may prompt from the Y-BOCS-SC obsessive-compulsive symptoms. group genotyping cross-cultural consistency. Different symptom clusters with different clinical characteristics of patients with obsessive-compulsive disorder. (2) quality of life of patients with obsessive-compulsive disorder is lower than the normal population. The severity of obsessive-compulsive symptoms associated with depressive symptoms is an important factor of the quality of life of obsessive-compulsive disorder. (3) the quality of life in patients with obsessive-compulsive disorder symptom clusters differences, compared with the inspection and symmetrical cluster of symptoms in patients with damage to the storage symptom clusters of the quality of life in patients with the field of the environment, the field of psychology, the field of social relations heavier, washing symptom clusters patients with more serious physiological damage to the field.
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