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Objective:: Currently, Graves disease(GD), Hashimoto’s thyroiditis(HT)and subacute thyroiditis(SAT) were the most common thyroid diseases.Graves disease and Hashimoto’s thyroiditis were organ-specific autoimmunediseases, subacute thyroiditis was associated with viral infection andautoimmunity. In addition to its established role in calcium metabolism andskeletal homeostasis, vitamin D was recently identified as a factor playing arole in both innate and adaptive immunity. Currently available clinical studiesreported a high prevalence of vitamin D deficiency in patients with severalautoimmune diseases, including multiple sclerosis, rheumatoid arthritis, type1diabetes mellitus, and Crohn’s disease. There were many studies reportvitamin D deficiency was associated with Graves disease and Hashimoto’sthyroiditis abroad. Some domestic studies reported that patients with lowserum levels of vitamin D, who suffered from Graves’ disease or Hashimoto’sthyroiditis, daily were given oral supplementation of1,25-(OH)2D3besidesconventional treatment achieved good therapeutic effect. In the present study,we evaluated the vitamin D status in patients with newly onset GD, HT andSAT and the association of serum vitamin D levels with the clinical factorsrelated to the three thyroid diseases above.Method: Totally93patients with newly onset thyroid diseases, including35with GD,30with HT and28SAT, were consecutively recruited from thesubjects who attended the department of endocrinology of the Second Hospitalof Hebei Medical University from June to November in2013. Serum free T3(FT3)、free T4(FT4), TSH, TPOAb, and lipids (TG, CHOL, HDL, LDL) weremeasured. In addition, TRAb, TGAb, erythrocyte sedimentation rate (ESR),and high-sensitivity C-reactive protein were checked according to the disease.The thyroid volume were calculated according to the thyroid ultrasound. Statistical analyses were performed by software SPSS17.0. A two-sided valueof P <0.05was considered statistically significant.Result:1Among four group, serum25-(OH)D3levels were statisticallysignificant different. NC group comply with the normal distribution, theaverage of serum25-(OH)D3of NC group were (39.96±4.11) ng/mL, themedian f serum25-(OH)D3of GD group were23.62ng/mL, the interquartilerange were18.00ng/mL, the median of serum25(OH)D3of HT group were6.85ng/mL, the interquartile range were5.57ng/mL, the median f serum25(OH)D3of SAT group were8.17ng/mL, the interquartile range were8.74ng/mL. Serum levels of25-(OH)D3in four groups were statistical differentsignificantly by rank sum test(P <0.05), NC group were shown larger thanGD, HT, and SAT group by pairwise comparison and the differences werestatistically significant. GD group were shown larger than HT, SAT group andthe difference was statistically significant. HT group and NC group had nostatistical significance (P>0.05).2For objects of four group,We found a positive correlation between theserum25-(OH)D3and FT3(r=0.295, P=0.000), FT4(r=0.357, P=0.000).Serum25-(OH)D3were negative correlated with TSH (r=0.297, P=0.000).Serum25-(OH)D3had no significant correlation with TRAb, TGAb, TPOAband thyroid volume. Serum25-(OH)D3levels were negative associated withCHOL (r=0.282, P=0.000), LDL (r=0.328, P=0.000).25-(OH)D3had noassociation wih TG and HDL.3Serum25-(OH)D3levels of NC group had no obvious correlation withthe other studying targets. Serum25-(OH)D3levels of GD and HT groups(autoimmune thyroid diseases) were significantly correlated with FT3(r=0.664, P=0.000), FT4(r=0.674, P=0.000), TSH (r=0.613, P=0.001), TPOAb(r=0.400, P=0.001), TRAb (r=0.562, P=0.000), TGAb (r=0.425, P=0.000),CHOL (r=0.501, P=0.000), LDL (r=0.434, P=0.000), HDL (r=0.308, P=0.012) and blood sugar (r=0.461, P=0.000). Serum25-(OH)D3levels of SATgroup were significantly correlated with sugar (r=0.411, P=0.03) and LDL (r=0.383, P=0.044). Correlation coefficient R and P value were shown asabove.Conclusion：1Serum25-(OH)D3levels of the three common thyroid diseases (Gravesdisease, Hashimoto’s thyroiditis and subacute thyroiditis) were significantlylower than the healthy controls. Among the three case groups, serum25-(OH)D3levels of Hashimoto thyroiditis and subacute thyroiditis were theminimum.2Serum25-(OH)D3levels of autoimmune thyroid disease (Gravesdisease with Hashimoto’s thyroiditis) were positively correlated with FT3, FT4,and TRAb, as well as negatively correlated with TPOAb, TGAb, TSH, CHOL,LDL, HDL. There was no obvious correlation between serum25-(OH)D3levels and thyroid volume.3No obvious correlation was observed between serum25-(OH)D3levelsand thyroid hormones and antibodies in subacute thyroiditis patients. Bloodsedimentation and hypersensitive c-reactive protein had no obvious correlationwith serum25-(OH)D3levels in subacute thyroiditis patients.
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