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A Clinical Feature Analysis on Primary Hyperthyroidism Coexisted with Thyroid Cancer

Author: LiaoHuiJun
Tutor: ChangShi
School: Central South University
Course: Clinical
Keywords: Primary hyperthyroidism Thyroid carcinoma Epidemiologic Clinical feature
CLC: R581.1
Type: Master's thesis
Year: 2013
Downloads: 15
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Objective:To study the epidemiologic and clinical features of primary hyperthyroidism coexisted with thyroid cancer.Methods:Clinical data of30cases primary hyperthyroidism accompanying with thyroid cancer (research group) in365primary hyperthyroidism treated by operation from January2002to Jun2011, contrasted with30hyperthyroidism without thyroid cancer (hyperthyroidism group) and30thyroid cancer without hyperthyroidism (cancer group) which were taken out randomly at the same time, were retrospectively reviewed.Results:The incidence of thyroid cancer in surgical treatment of primary hyperthyroidism was8.22%(30/365); the average age of research group and hyperthyroidism group were40.77and33.0years old(P<0.05); the median course in two group respectively were875.0and1460days(P<0.05); the median course of research group and cancer group were875.0and120.0days separately(P<0.05); the detection rate of thyroid nodule by preoperative ultrasound in research group and hyperthyroidism group were100.0%(30/30) and30.0%(9/30)(P<0.05); the detection rate of microcalciffcation by preoperative ultrasound in observation, hyperthyroidism, cancer group were80.0%(24/30),6.7%(2/30),56.7%(17/30), the rate of research group was higher than hyperthyroidism group(P<0.05) and cancer group(P<0.05); the preoperative diagnostic rate of thyroid cancer is40.0%(12/30) and66.7%(20/30) separately (P<0.05) in research group and cancer group, the average diameter of the two group were14.00mm and23.56mm(P<0.05), lymph nodes metastasis rate in research group and in cancer group were20.0%(6/30) and46.7%(14/30)(P<0.05); all patients were followed up for1month-114months and a half with an average of4.5years;1case (3.3%) recurred hyperthyroidism in research group at5years after surgery; in hyperthyroidism group1case recurred hyperthyroidism2years after surgery, and1case recurred at6years after surgery; in cancer group1case (3.3%) recurred thyroid cancer at1year after surgery and received operation again,1case (3.3%) died from respiratory failure caused by lung metastasis of thyroid cancer.Conclusions:1) The rate of thyroid cancer in surgical treatment of primary hyperthyroidism is higher than in general population.2) The age of patient with primary hyperthyroidism coexisted with thyroid cancer is older than the patient with hyperthyroidism, the course was shorter than primary Hyperthyroidism, but longer than thyroid cancer patients.3) Thyroid cancer in surgical treatment of primary hyperthyroidism had high preoperative misdiagnostic rate, microcalciffcation was the special feature at ultrasonic in hyperthyroidism coexisted with thyroid cancer.4) When primary hyperthyroidism coexisted with thyroid cancer, the diameter of tumor was short and lymph nodes metastasis rate was low.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Thyroid disease > Hyperthyroidism
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