Dissertation > Excellent graduate degree dissertation topics show

Adverse Reactions of Gemcitabine Combined with Cisplatin in Treating Muscle-invasive Urothelial Carcinoma

Author: WangZhiPeng
Tutor: TianYe
School: Capital University of Medical Sciences
Course: Surgery
Keywords: Urothelial carcinoma Gemcitabine Cisplatin Chemotherapy
CLC: R737.15
Type: Master's thesis
Year: 2013
Downloads: 6
Quote: 0
Read: Download Dissertation

Abstract


ObjectiveTo evaluate the adverse reactions of gemcitabine combined with cispaltin intreating muscle-invasive urothelial carcinoma.MethodsFifty-three patients with muscle-invasive urothelial carcinoma, includingthirty-seven patients with bladder cancer, eight patients with renal pelvis cancer, fourpatients with ureter cancer and four patients with multiple urothelial carcinoma,treated with gemcitabine(800mg/m2) that was dripped intravenously in30minutes onday1, day8and day15, and cisplatin (70mg/m2) that was dripped lucifugal in2hours on day2.The regimen was repeated every28days. Each patient received atleast two cycles. Adverse reactions was evaluated after two cycles.ResultsThe fifty-three patients finished one hundred and fifty-nine cycles. The mainadverse reactions were myelosuppression and gastrointestinal adverse reaction.Different degree myelosuppression appeared in every patient, manifestations of whichincluding decreased white blood cell, blood platelet and hemoglobin. With the ageincreasing, occurrence rate of II~III degree decreased blood platelet and hemoglobinsignificantly increased(P=0.003,P=0.000). Gastrointestinal adverse reaction appearedin thirty-eight patients, manifestations of which including nausea, vomit, poorappetite and constipation. Liver and renal toxicity appeared in twenty-six patients,alopecia in seven patients, rash in three patients. No serious complications wereencountered in all patients.ConclusionAdverse reactions of gemcitabine combined with cisplatin in treating themuscle-invasive urothelial carcinoma is safe and can be tolerated by patients.

Related Dissertations

  1. Effect of Rh-Endostatin on the Expression of ERCC1 in Human Lung Adenocarcinoma A549 Cells,R734.2
  2. The Expression and Clinical Significance of Ercc1 in Human Gastric Cancer,R735.2
  3. Influence on NF-κB P65 and ASPP2 of Murine Lewis Lung Cancer of NF-кB Inhibitor PDTC and Cisplatin,R734.2
  4. Glioma resistance related gene expression and its clinical significance,R739.4
  5. A Retrospective Study on Chemotherapy-induced Amenorrhea in Premenopausal Women with Breast Cancer,R737.9
  6. Pharmacoepidemiology Study of Anti-lung Cancer,R734.2
  7. The Quality Control Research of Gemcitabine Hydrochloride and Gemcitabine Hydrochloride for Injection,R943
  8. Analysizing the Cases with the Persistent Low-level Human Chorionic Gonadotropin in the Serum and Reviewing of the Literatures,R714.2
  9. Clinical Observation of Wujing Ointment in Reducing Adverse Reactions Attached to Asthenia of Spleen and Pathogenic Damp of FOLFOX4 in Treating Cancer of Colorectum,R285
  10. Blood treasure Mixture on leukopenia induced by cyclophosphamide in mice Experimental Study on Effects,R285
  11. The Expressions of Different Proteins in Paclitaxel-sensitive and Resistant in Human Breast Cancer Cells,R273
  12. Clinical Study on Cancer-related Anemia Treated by ’Yi Xue Fang Prescription’,R273
  13. Clinical Study on Advanced Non-small Cell Lung Cancer Treated by TCM Centralizer Combined with Chemotherapy,R273
  14. Influence of Neoadjuant Chemotheratpy on Biological Behaviour of Osteosarcoma and Clinical Meaning,R738
  15. Synergistic Augmentation of Cisplatin-induced Apoptosis in Hela Cells by Rapamycin,R737.33
  16. The Effects of Chemotherapy Education Intervention on Quality of Life, Knowledge, Attitude and Behavior in Cancer Patients,R473.73
  17. The Role of 5-HT Involved in the Mechanism of Preventing Chemotherapy-induced Nausea and Vomiting of Forsythia Suspensain in Rat Pica Model,R285.5
  18. Experimental Study of Antiemetic Effect and 5-HT Mechanism of Xiao-Ban-Xia-Tang in Chemotherapy-induced Rat Pica Model,R273
  19. Clinical Observation on Treatment of Chemotherapy-induced Peripheral Nerve Toxicity with Yiqitongluo Fang,R273
  20. The Clinical Research on the Treatment of Ovarian Tumour by Lichongshengsuiyin Combined with Chemotherapy,R273
  21. Theory and Clinical Research for the Treatment of Postoperative Gastric Cancer Who Had the Sydrom of Spleen Deficency Blood Stasis with the Method of Jianpi Huayu,R273

CLC: > Medicine, health > Oncology > Genitourinary tumors > Urinary tumors > Urinary tract tumors
© 2012 www.DissertationTopic.Net  Mobile