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The Comparison and Correlation of Pulmonary Function and Nitric Oxide to Evaluate the State of Clinical Control in Children of Asthma Remission

Author: WangZuo
Tutor: HuangYan
School: Dalian Medical University
Course: Pediatrics
Keywords: Clinical remission of asthma Asthma control Pulmonary function Fraction of exhaled nitric oxide Children
CLC: R725.6
Type: Master's thesis
Year: 2013
Downloads: 20
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Abstract


Objective: To realize the state of pulmonary function and airway inflammationin clinical remission of asthma in children. To evaluate the state of asthma control byusing pulmonary function test and exhaled nitric oxide test, and correlation of the twomonitoring methods.Methods: In our current study the data was collected from December2010toJanuary2013in Dalian children hospital. Fifty children at the age range of4to15year were admitted. All of the children had used inhaled corticosteroid in a standardand systematic way, and at clinical remission of asthma. Then the pulmonary functionand fraction of exhaled nitric oxide were measured in order to know about the state ofpulmonary function and airway inflammation, assess the asthma control by usingpulmonary function test and exhaled nitric oxide test, and analysis the correlation ofthe two monitoring methods.Results:1.Among50patients,17(34℅) children pulmonary function was mild abnormal.Within these17patients,13(26℅) patients’ small airway function was retrogressed;3(6℅) patients had obstructive airway function and1(2℅) patient had both obstructiveand restrictive state.2.In total amount of patients,46(92℅) were completely and4(8℅) werepartially controlled.3.Thirty three(66℅) patients were having abnormal fraction of exhaled nitricoxide. Among the33cases,21(42℅) patients had mild grade of high consistency and12(24℅) patients had obvious grade of high consistency. The fraction of exhalednitric oxide of the50patients were significantly higher than healthy children(T＝45，P＜0.01). 4.The fraction of exhaled nitric oxide among50children,4patients who hadpartial control were abnormal. And in other46cases,29(63℅) patients had high nitricoxide consistency.46patients were divided into two(normal and retrogressive) groupsbased on small airway function,33patients having normal small airway function,19(58℅) patients’ nitric oxide consistency was higher and13patients havingretrogressive small airway function,10(77℅) patients had higher consistency of nitricoxide.5.When evaluating the state of asthma control, the significant differencebetween pulmonary function and fraction of exhaled nitric oxide was observed(x2＝27.03，P＜0.01).6.There was no significant correlation between pulmonary function and fractionof exhaled nitric oxide in clinical remission of asthma(P＞0.05).Conclusion:1.One-third patients had abnormal pulmonary function in clinical remission ofasthma, most of the small airway function were retrogressed. Although patients hadused inhaled corticosteroid in a standard and systematic manner, still two-thirds ofpatients had airway inflammation in clinical remission of asthma.2.During asthma control, the airway inflammation was still uncontrolled. Thepatient whose small airway function was retrogressed, four-fifths had airwayinflammation.3.Pulmonary function and fraction of exhaled nitric oxide played different rolesto evaluate the clinical control of asthma remission. Pulmonary function reflectedventilation function, and fraction of exhaled nitric oxide reflected the level of airwayinflammation.4.While evaluating the state of clinical control in asthma remission, pulmonaryfunction test and fraction of exhaled nitric oxide test could not substitute for eachanother. The important clinical significance to bring exhaled nitric oxide into routinewas observed while evaluating the diagnosis and treatment of asthma.

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CLC: > Medicine, health > Pediatrics > Children within the science > Department of pediatric respiratory and chest diseases
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