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Impact of Syndrome and CNVs on the Outcome of Surgery of Conotruncal Heart Defects

Author: HuangXiaoJie
Tutor: YangYiFeng
School: Central South University
Course: Clinical
Keywords: congenital heart defects conotruncal heart defects geneticsyndrome copy number variants
CLC: R726.5
Type: Master's thesis
Year: 2013
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Abstract


Objective:To observe the impact of genetic syndrome and copy number variants(CNVs) on the outcome of primary surgical repair of conotruncal heart defects.Methods:This retrospective study reviews the outcome of263consecutive patients who underwent primary repair of Tetrology of Fallot(TOF) and Double Outlet Right Ventricle(DORV) between July2010to December2012.263patients were divided into groups according to whether complicated with genetic syndromes or detected CNVs. The postoperative durations of incubation, CICU stay and hospitalized period were recorded. The morbidity of arrhythmia, ventilator-associated pneumonia(VAP) and low cardiac output syndrome(LCOS) were calculated. The early postoperative mortality and the incidence of reoperation and reincubation were also recorded. Data analysis was performed by SPSS19.0.Results:Primary surgical repair was accomplished in all263patients. Significantly prolonged postoperative durations of incubation, CICU stay and hospitalized period were observed in syndromic patients and CNVs(+) patients(P<0.05). Compared to patients with CNVs(+)Syn(+) and CNVs(+)Syn(-), postoperative durations of incubation, CICU stay and hospitalized period of patients with CNVs(-)Syn(+) were significantly prolonged(P<0.05). The morbidity of ventilator-associated pneumonia(VAP) and low cardiac output syndrome(LCOS) was significantly higher in syndromic patients and CNVs(+) patients(P<0.05) while mortality was of no significant difference among groups.Conclusions:Syndromic patients and CNVs(+) patients exhibit prolonged recovery time and higher incidences of ventilator-associated pneumonia(VAP) and low cardiac output syndrome(LCOS) after primary repair of conotruncal heart defects.

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