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The Relationships between Endogenous Granulocyte Colony-Stimulating Factor and White Blood Cell of Lung Small Cell Lung Cancer

Author: QuJingJing
Tutor: HuChengPing
School: Central South University
Course: Clinical
Keywords: Endogenous Granulocyte Colony-Stimulating Factor NonSmall Cell Lung Cncer White Blood Cell chemotherapy
CLC: R734.2
Type: Master's thesis
Year: 2013
Downloads: 15
Quote: 0
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Background and Objective:For the past few years, diagnostic technique of malignant tumor have been acquired comparatively large progression.But a lot of them is advanced stage when they have last diagnosis and lost surgery chance. Chemotherapy remain the therapeutic method.Adverse reaction of chemotherapy affect the patient compliance and curative effect.Bone marrow depression is the main adverse reaction in chemotherapy. Tumor cell can secretion growth factor like GranulocyteColony-StimulatingFactor(G-CSF),Granulocyte-Macrophage Colony-Stimulating Factor(GM-CSF), Macrophage Colony-Stimulating Factor(M-CSF).G-CSF in the cores factor to regulation white blood cell,maybe G-CSF relevant with the descended white blood cell of chemotherapy. This research to approach the relationships between endogenous granulocyte colony-stimulating factor and white blood cell of Lung Small Cell Lung Cancer.Methods:Use the prospective methord to collect the94final diagnosis of NSCLC and recod their WBC,G-CSF count.The chemotherapy program use bi-platin,then recod their WBC,G-CSF count after the six days of chemotherapy. According to the WBC count after chemotherapy to grouping the G-CSF and comparison the G-CSF. Analyse diversifys relationships between WBC, G-CSF and analyses their correlation.Results:(1)94NSCLC have been selected,71NSCLC accept the chemotherapy.After chemotherapy the WBC count is infra-prechemotherapy(4.1×109/L VS8.9×109/L P<0.05).After chemotherapy the G-CSF count is infra-prechemotherapy(147.37±22.79pg/ml VS161.56±17.7pg/ml P<0.05).(2)According to the WBC count, the G-CSF of descend group is clearly infra-other group(97.46±45.4pg/ml VS150.14±52.4pg/ml、373.68±78.9pg/ml、111.10±45.4pg/ml P<0.05).According to the WBC ratios,the G-CSF of descend group is also clearly infra-other group(2.40±32.1pg/ml vs145.84±22.4pg/ml、273.68±58.9pg/ml、131.10±28.9pg/ml P<0.05).(3)30case descend group of WBC after chemotherapy the G-CSF count is infra-prechemotherapy(34.50±27.99pg/ml VS88.89±49.1pg/ml P<0.05).(4)Correlation analyses of WBC and endogenous granulocyte colony-stimulating factor,correlation coefficient is0.265and0.149(P<0.05).Correlation analyses of neutrophilic granulocyte and endogenous granulocyte colony-stimulating factor,correlation coefficient is0.182and0.189(P<0.05). Conclusions:Chemotherapy affect the white blood cell descent of NSCLC is relevant with the endogenous G-CSF.The endogenous granulocyte colony-stimulating factor and after WBC count of NSCLC is positive correlation.

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