Dissertation > Excellent graduate degree dissertation topics show

The Relationships between Endogenous Granulocyte Colony-Stimulating Factor and White Blood Cell of Lung Small Cell Lung Cancer

Author: QuJingJing
Tutor: HuChengPing
School: Central South University
Course: Clinical
Keywords: Endogenous Granulocyte Colony-Stimulating Factor NonSmall Cell Lung Cncer White Blood Cell chemotherapy
CLC: R734.2
Type: Master's thesis
Year: 2013
Downloads: 15
Quote: 0
Read: Download Dissertation

Abstract


Background and Objective:For the past few years, diagnostic technique of malignant tumor have been acquired comparatively large progression.But a lot of them is advanced stage when they have last diagnosis and lost surgery chance. Chemotherapy remain the therapeutic method.Adverse reaction of chemotherapy affect the patient compliance and curative effect.Bone marrow depression is the main adverse reaction in chemotherapy. Tumor cell can secretion growth factor like GranulocyteColony-StimulatingFactor(G-CSF),Granulocyte-Macrophage Colony-Stimulating Factor(GM-CSF), Macrophage Colony-Stimulating Factor(M-CSF).G-CSF in the cores factor to regulation white blood cell,maybe G-CSF relevant with the descended white blood cell of chemotherapy. This research to approach the relationships between endogenous granulocyte colony-stimulating factor and white blood cell of Lung Small Cell Lung Cancer.Methods:Use the prospective methord to collect the94final diagnosis of NSCLC and recod their WBC,G-CSF count.The chemotherapy program use bi-platin,then recod their WBC,G-CSF count after the six days of chemotherapy. According to the WBC count after chemotherapy to grouping the G-CSF and comparison the G-CSF. Analyse diversifys relationships between WBC, G-CSF and analyses their correlation.Results:(1)94NSCLC have been selected,71NSCLC accept the chemotherapy.After chemotherapy the WBC count is infra-prechemotherapy(4.1×109/L VS8.9×109/L P<0.05).After chemotherapy the G-CSF count is infra-prechemotherapy(147.37±22.79pg/ml VS161.56±17.7pg/ml P<0.05).(2)According to the WBC count, the G-CSF of descend group is clearly infra-other group(97.46±45.4pg/ml VS150.14±52.4pg/ml、373.68±78.9pg/ml、111.10±45.4pg/ml P<0.05).According to the WBC ratios,the G-CSF of descend group is also clearly infra-other group(2.40±32.1pg/ml vs145.84±22.4pg/ml、273.68±58.9pg/ml、131.10±28.9pg/ml P<0.05).(3)30case descend group of WBC after chemotherapy the G-CSF count is infra-prechemotherapy(34.50±27.99pg/ml VS88.89±49.1pg/ml P<0.05).(4)Correlation analyses of WBC and endogenous granulocyte colony-stimulating factor,correlation coefficient is0.265and0.149(P<0.05).Correlation analyses of neutrophilic granulocyte and endogenous granulocyte colony-stimulating factor,correlation coefficient is0.182and0.189(P<0.05). Conclusions:Chemotherapy affect the white blood cell descent of NSCLC is relevant with the endogenous G-CSF.The endogenous granulocyte colony-stimulating factor and after WBC count of NSCLC is positive correlation.

Related Dissertations

  1. Study of Sepia Ink-Astragalus Preparation for Relieving Damage Caused by Chemotherapy,R285.5
  2. The Protective Effects of Glucagon-like Peptide -2 on Intestinal Barrier Function of Doxorubicin Chemotherapy in Rats,R730.5
  3. Glioma resistance related gene expression and its clinical significance,R739.4
  4. Cancer patients before and after chemotherapy changes in blood glucose and glycosylated hemoglobin,R587.1
  5. The Relationship Between Polymorphisms in XPG C46T Gene and Chemotherapy in Colorectal Carcinoma,R735.3
  6. Relationship between Acute Hyperglycemia and Prognosis in Patients with Acute Myocardial Infarction,R542.22
  7. Proteomics Approach Screening Breast Cancer Drug Resistive and Sensitive Serum Marker,R737.9
  8. Study of Dendriti Cell Treatment Combined with Chemotherapy for Late Gastric Cancer,R735.2
  9. Evaluation of DWI and MR Spectroscopy of 3.0T MR in Cervical Cancer,R445.2
  10. Mining Predictive Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer by Proteomics,R735.2
  11. The Different Serum Proteomics Analysis in in Patients with Esophageal Neoplasms Treated by Chemoradiation in Kazak Nationality in Xinjiang,R735.1
  12. The Clinical Efficacy Analysis of Different Ways of Neoadjuvant Chemotherapy in Cervical Cancer,R737.33
  13. Analysizing the Cases with the Persistent Low-level Human Chorionic Gonadotropin in the Serum and Reviewing of the Literatures,R714.2
  14. Clinical Observation of Wujing Ointment in Reducing Adverse Reactions Attached to Asthenia of Spleen and Pathogenic Damp of FOLFOX4 in Treating Cancer of Colorectum,R285
  15. The Expressions of Different Proteins in Paclitaxel-sensitive and Resistant in Human Breast Cancer Cells,R273
  16. The Evaluation of Xiao Gu Fang Jointing Cisplatin with Treat of Cancer Nature Ascites,R730.5
  17. Evaluation of 3T MR Quantitative T1 Perfusion in Differential Diagnosising Human Breast Lesions,R445.2
  18. Investigation and Analysis of Chemotherapy in Cancer Patients Hospitalized from 2008-2010 in the Department of Thoracic Surgery,R96
  19. Qi Diuresis intraperitoneal cisplatin treatment of malignant Ascites,R730.5
  20. The Clinical Analysis of Recombinant Human Endostatin Combined with Chemotherapy for 17 Patients with Malignant Tumors,R730.5
  21. Clinical Value of PCT in the Adult Community-Acquired Pulmonary,R563.1

CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
© 2012 www.DissertationTopic.Net  Mobile