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The Study of Nanoporous TiO2Coating Modification on the Surface of Titanium Dental Implants

Author: ZuoYang
Tutor: XiaRong
School: Anhui Medical University,
Course: Stomatology
Keywords: Sol gel method Nano structure Titanium TiO2
CLC: R783.1
Type: Master's thesis
Year: 2013
Downloads: 28
Quote: 0
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Objective:This experiment takes the pure titanium specimen as the research object.Sol gel method was used to build a nanoscale porous structure in the plate surface.The titanium plate surfaces were observed and analyzed by SEM, XRD and EDX.Ratmensenchymal stem cell (MSC) was cultured in vitro to observe the biocompatibility.Methods: Commercially pure titanium plate were utilized in this study.The diameterwas10mm,the thickness was2mm.The surfaces of the titanium plate were polishedby800#、1000#、1500#、2000#、3000#、and5000#sandpaper in turn.The specimenswere ultrasonic cleaned in acetone, anhydrous ethanol and ultrapure water for10minutes respectively,then in the oven the plate was dried at60℃for1hour.Thesmooth titanium plate was set as the control,while the nano as the experimental group.The solution A was preparated with butyl titanate, anhydrous ethanol and ethyleneglycol amine,the solution B was preparated with anhydrous ethanol and water. Thesolution B has be droped into the solution A slowly,then polyethylene glycol (peg)2000has be added into the solution,stirred for2hours. The sol gel solution was droppedonto the titanium plate surface in vacuum. The plate was put in the oven for10minutes at100℃,then in the resistance furnace for1hour at550℃.The structure morphology, element composition and chemical composition of thecontrol group and experimental group were observed through SEM, XRD and EDX.The marrow mesenchymal stem cells were cultivated in vitro,and the cells werevaccinated to the two plate surface in the density of5x105/ml. The plate wascleaned by PBS on the third day,then glutaraldehyde solution was dropped into theplate to fix the cells. The adhesion of cells on the plate was observed by SEM.Thecells were vaccinated to the two plate surface in the density of5x104/ml, theproliferation condition was detected by CCK-8. The cell concentration was adjust to1x105cells/ml,and the differentiation was detected by alkaline phosphatase.Results: The structure morphology of the control group is very smooth and flat underthe SEM,and the EDX shows that the elements of the control group is titanium.Underthe SEM,the experimental group titanium plate formed nanoscale porous morphology,the diameter of the aperture is about50-100nm,and the micro hole pitch is about100-200nm. The result of EDX shows the elements of the experimental group aremainly titanium and oxygen. The spectrum of XRD detects the main chemicalcomposition of the experimental group surface is titanium dioxide.The SEM shows marrow mesenchymal stem cells adhere well in the experimental group,but growslowly in the control group.The OD values of experimental group are higher thancontrol group, and difference is statistically significant(P <0.05).Alkaline phosphatasedetection results show OD values of experimental group are higher than control group,the difference is statistically significant (P <0.05).Conclusion:The roughness of the titanium plate surface, especially the nanoscaleroughness are more likely to enhance the biological reactions, promote the growth andadhesion of MSC on the implant surface. The nanoscale porous TiO2coating can beformed on the titanium plate surface by the sol gel method. Nanoscale titaniumdioxide has good biological activity, stability and anti-corrosion effect, so the sol gelmethod could be an effective method for implant surface modification in the future.

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CLC: > Medicine, health > Oral Sciences > Oral orthotics > Dental Materials Science
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