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Objective: This article by measuring serum high sensitivity C-reactive protein (hs-CRP) levels were observed acute atherosclerotic cerebral infarction in patients with carotid atherosclerotic plaques nature to explore the C-reactive albumin and carotid atherosclerotic plaques Block property relationships and high-sensitivity C-reactive protein in atherosclerotic cerebral infarction occurred in the meaning; addition, serum malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) and other indicators explore the hs-CRP and oxidative stress may be the relationship between stress and hs-CRP relationship with the severity of cerebral infarction. Method: 1. Collect 83 cases of carotid atherosclerosis in cerebral infarction patients and 25 healthy control subjects were compared between serum hs-CRP, lipid profile (TC, TG, LDL-C, HDL-C) , MDA, SOD and NO. (2) In cases of cerebral infarction group, according to the results of carotid ultrasonography, sub-group of soft plaque and hard plaque group, no plaque group three subgroups, the line above serological comparison. 3 MRI area according to the size of the cerebral infarction group was divided into: ① large infarction group: more than one lobe, 50mm or more. ② in the MI group: less than one lobe, 31 ~ 50mm. ③ small infarction: 16 ~ 30mm, compared three groups serological markers and plaque above nature. Results: 1, in the cerebral infarction group and the control group, there are significant differences in hs-CRP, TC, GLU, MDA, SOD and NO (P lt; 0.05). 2 to plaque stability to the nature of subgroups, the results show different between patients with cerebral infarction plaque nature hs-CRP, LDL, NIHSS, MRI area the size of MDA, SOD and NO was statistically significant (P lt; 0.05). 3, with cerebral MRI area of ??subgroups, the results three groups hs-CRP, MDA, NO, SOD, LDL, NIHSS there are differences between (P lt; 0.05). 4, correlation analysis showed: plaques and cerebral infarct size compared rank correlation plaque stability prompted worse, more severe cerebral infarction; hs-CRP level was the nature of plaque rank correlation, hs-CRP increases, the spot block more unstable nature, controlling factors and infarct size after oxidative stress indicators still makes sense; hs-CRP positively correlated with MDA and SOD negatively correlated with the size of the infarction area was positively correlated with level of rank; cerebral infarct size and MDA, NO was positively correlated, negatively correlated with SOD. (The relevant indicators P lt; 0.05). Conclusion: ① hs-CRP is a reflection of carotid atherosclerotic plaque stability properties of serological markers may be acute carotid atherosclerotic cerebral infarction predictors. ② body hs-CRP levels, higher severity of cerebral infarction, suggesting that hs-CRP as inflammatory mediators may reflect the condition and prognosis of cerebral infarction may be related to oxidative stress involved with cerebral ischemia-reperfusion injury in the process.
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