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Expression of bFGF and TGF-β1 in Benign Prostatic Hyperplasia Combined with Prostatitis and Their Significances

Author: ChenZhiPeng
Tutor: CaoLinSheng;ZhouHuiLiang
School: Fujian Medical
Course: Surgery
Keywords: Prostatitis Prostatic hyperplasia bFGF TGF-β1 Immunohistochemistry Immunofluorescence quantitative PCR
CLC: R697.32
Type: Master's thesis
Year: 2010
Downloads: 49
Quote: 1
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Abstract


Objective: To detect simple benign prostatic hyperplasia (benign prostatic hyperplasia, BPH) and prostatitis, BPH patients combined bFGF, TGF-β1 gene and protein expression differences , explore the development of inflammation and BPH relationship . Methods: 60 cases of transurethral resection (TURP) in patients with BPH prostate specimens , routine HE staining of BPH and the incidence of chronic prostatitis and inflammatory infiltration sites and grading situation . Immunohistochemistry and immunofluorescence quantitative PCR bFGF and TGF-β1 in prostate tissue expression . Results : 1. HE staining results : BPH with chronic prostatitis incidence of 61.67% , accounting for 48.64% with mild , moderate, accounting for 32.43% , accounting for 18.91% severe . In all cases of inflammation , whether mild, moderate , severe , have varying degrees of interstitial gland week and glandular inflammatory cell infiltration. 2 Immunohistochemical results : 60 cases of hyperplastic prostate tissue were expressed bFGF and TGF-β1, and chronic inflammation of the prostate tissue was significantly higher than simple hyperplasia group (P lt; 0.01); and with the severity of inflammation different bFGF, TGF-β1 protein expression differences (P lt; 0.05). 3 immunofluorescence quantitative PCR Results: 60 cases of hyperplastic prostate tissue were expressed bFGF and TGF-β1mRNA. Chronic inflammation of the prostate tissue was higher than simple hyperplasia group (P lt; 0.05). Simple hyperplasia group of bFGF and TGF-β1 mRNA was the lowest , mild to moderate inflammation gradually increased inflammation and severe inflammation of the highest concentrations (P lt; 0.05). Conclusions : BPH merger is not high probability of prostatitis . Prostatitis promote prostate tissue bFGF and TGF-β1 protein expression and correlation with the degree of inflammation , suggesting that inflammation may be involved in the development and progression of BPH .

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CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Male genital diseases > Prostate disease > An enlarged prostate
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