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Objective: To observe the Chapa Rui celecoxib laparoscopic Dixon surgery (sigmoid rectal resection anastomosis surgery) in patients with postoperative pain and IL-12, IL-4 impact. Methods: ASA Ⅰ - Ⅱ 30 cases of laparoscopic Dixon, general anesthesia surgery patients were randomly divided into three groups: group A (preoperative group, n = 10), 12 hours after induction and induction intravenous parecoxib 40mg to the same amount of surgery after skin closure saline; B group (postoperative group, n = 10), 12 hours after the operation, after skin closure and induction of intravenous parecoxib 40mg, induction to normal saline; C group (control group, n = 10), three time points were given saline. Recorded after 2 hours, 4 hours, 6 hours, 8 hours, 12 hours, 20 hours, 24-hour pain visual analog score (VAS), recording 24 hours after the patient analgesia overall impression score and tramadol dosage . Induction prior to administration (T0), after 2 hours (T1), after 12 hours (T2), 24 hours after surgery (T3) blood serum IL-12, IL-4 level. Records such as nausea, vomiting within 24 hours after the occurrence of the adverse reactions and liver and kidney function. Results: The three groups of patients age, height, body mass index, gender, duration of surgery, anesthetic usage and access to water was no significant difference (P gt; 0.05). ① after surgery at each time point, the the medication two groups of patients VAS scores lower than the control group (P lt; 0.05), slightly lower than the postoperative group preoperative group, but no statistical significance (P gt; 0.05); medication both groups After 24 hours in patients with subjective ratings of analgesic treatment than the control group (P lt; 0.05) and tramadol amount is less than the control group (P lt; 0.05), preoperative group and postoperative group difference was not statistically significant ( P gt; 0.05); ② postoperative IL-12 decreased and then increased the postoperative drug two groups at each time point higher than that in control group (P lt; 0.05), and picked up speed faster than the control group, the preoperative group and postoperative There was no significant difference (P gt; 0.05). ③ IL-4 after than before surgery increased each point in time of the postoperative treatment group than the control group, fell faster than the control group (P lt; 0.05), slightly lower than the preoperative group postoperative group, but the difference was not statistically significance (P gt; 0.05). ④ IL-12/IL-4 ratio trend similar to IL-12 the medication two groups at each time point ratio higher than that in the control group (P lt; 0.05), preoperative group is slightly higher than the postoperative group, but the difference was not statistically significant (P gt; 0.05). ⑤ groups between the incidence of adverse reactions was no significant difference (P gt; 0.05), postoperative R, SPO2, liver and kidney functions were within the normal range. Conclusion: 1, parecoxib 40mg, 12 hours after repeated administration of postoperative the Dixon patients undergoing laparoscopic analgesic effective and well tolerated in patients. Preoperative administration immediately after administration was no significant difference in analgesic effect. 2, parecoxib both preoperative or postoperative administration can increase the secretion of IL-12 and inhibit the secretion of IL-4, elevated IL-12/IL-4 ratio, inducing perioperative TH0 to TH1 differentiation, there conducive to anti-infection immunity.
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