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Objective evaluation of TDI parameters organophosphorus pesticide poisoning effect on cardiac function in clinical application methods selected in January 2008 - January 2010 AOPP patients (n = 78) in accordance with the clinical manifestations and cholinesterase (CHE) measured value will be divided into mild to moderate poisoning group (AOPP-A-group, n = 42, age of 44.02 ± 13.87 years), severe poisoning group (AOPP-B-group, n = 36, age of 49.89 ± 17.04 years), and normal control group (NM , n = 32, age of 43.28 ± 11.62 years) to compare. Using a modified Simpson formula, left ventricular ejection fraction (EF). Conventional pulse Doppler measurements two, tricuspid diastolic peak E velocity (E), A peak velocity (A), E peak deceleration time (DT), isovolumic relaxation time (IVRT), calculate E / A ratio. TDI measurements using the apical four-chamber apical two-chamber apical long axis six points systolic mitral annular motion peak velocity (Sm), early diastolic velocity (Em), late diastolic velocity (Am), three mitral annulus velocity wall (wall-Em), calculated Em / Am, the average Sm (M-Sm) Average Em (M-Em), M-Em/M-Am, E / Em and Tei index, automatic biochemical analyzer measurement AOPP group and normal control group, the plasma myocardial enzymes CK, CK-MB, LDH and CHE concentration. By comparing three different indicators of cardiac function and the relationship between the parameters to determine the TDI evaluation AOPP right heart dysfunction value. Results 1.AOPP-B group M-Sm, M-Em, M-Em/M-Am, right ventricular Sm, Em, Em / Am and CHE concentrations below the normal control group, also lower than AOPP-A group, with the difference was statistically significant (p lt; 0.05). 2.AOPP-A, B group Tei index, M-Am, E / M-Em, right ventricular Am, E / Em, plasma CK-MB, LDH, CK concentrations higher than the normal control group (p lt; 0.001), AOPP-B group was higher than that AOPP-A group (p lt; 0.001). AOPP-B group M-Sm and M-Em was positively correlated (r = 0.533, p lt; 0.001). 3.E/M-Em and LVIDd (r = 0.409, p lt; 0.001) were positively correlated with the M-Sm (r = -0.424, p lt; 0.001), M-Em (r = -0.703, p lt; 0.001), M-Em/M-Am (r = -0.610, p lt; 0.001) were negatively correlated. Right ventricular E / Em wall was positively correlated with the Tei index; with right ventricular Em, Em / Am was negatively correlated (p lt; 0.01). 4.CK-MB concentration of M-Sm (r = -0.346, p lt; 0.001), M-Em (r = -0.675, p lt; 0.001), M-Em/M-Am (r = -0.774, p lt; 0.001) were negatively correlated; with E / M-Em (r = 0.671, p lt; 0.001), left ventricular Tei index (r = 0.285, p lt; 0.01) were positively correlated. With right ventricular Tei index, Am, E / Em was positively correlated (p lt; 0.001); with right ventricular Sm, Em, Em / Am was negatively correlated (p lt; 0.001) 5.PAP and right ventricle Am, E / side wall Em, Tei index, plasma CK-MB concentrations were positively correlated (p lt; 0.001). PAP and Sm, Em, right ventricular Em / Am was negatively correlated (p lt; 0.001). 6 LV mitral E / A and the average Em / Am of a positive correlation (r = 0.511, p lt; 0.001), right ventricular E / A and the right ventricular Em / Am of a positive correlation (r = 0.652, p lt ; 0.001), left ventricular and right ventricular Em / Am was positively correlated (r = 0.673, p lt; 0.001), mitral annular M-Sm and M-Em was positively correlated (r = 0.673, p lt; 0.001). Mitral annular M-Em was positively correlated with M-Em/Am (r = 0.895, p lt; 0.001) .7. Use of CK-MB predict ventricular diastolic dysfunction in patients with AOPP area under the curve (AUC) was 0.849. Conclusions (1) AOPP patients prone to severe left ventricular diastolic dysfunction. (2) systolic mitral annular velocity of early detection of patients with normal ejection fraction AOPP systolic dysfunction. (3) TDI is the evaluation of cardiac function in patients with AOPP effective way. (4) plasma CK-MB can be used to predict patients with impaired cardiac function AOPP. (5) severe organophosphorus pesticide poisoning patients with left and right ventricular Tei index were increased, indicating that patients with severe AOPP systolic and diastolic function were damaged to varying degrees.
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