|
Depression is a high prevalence, high recurrence rate, high morbidity and high suicide rates of serious mental disorders, the prevalence rate as high as 20%, has become a major hazard to human health diseases. Pathogenesis of depression has a variety of inferences, but no clear conclusion, and its diverse clinical symptoms, complications, diagnosis of somatization to bring some problems. Currently antidepressant medicine is varied, but there are 20% -30% of patients after taking the inactive, while Chinese medicine treatment of depression has a unique advantage. In this study, based on previous studies, the use of traditional Chinese medicine enlightened particles 1-5 with antidepressant fluoxetine medicine for randomized, parallel, multi-center controlled study large samples for TCM individual strengths to provide treatment for depression basis, so as to effectively guide the clinical. Objective To observe the depression patient's age, gender, distribution of TCM, TCM and HAMD depression scale seven factors between enlightened particles 1-5 fluoxetine treatment of depression and clinical efficacy, and to monitor its Adverse reactions. Methods were observed in patients with depression 300 cases, of which 38 cases are not the end of the observation period, 22 cases fall for various reasons, as required to complete courses of 240 cases observed. Treatment group (CMB) to 190 cases syndromes are divided into five syndromes: liver qi stagnation 39 cases, 33 cases of liver spleen, liver phlegm 40 cases, 36 cases of heart and spleen, kidneys do not pay 42 cases were taking enlightened 1-5 granules; control group (western medicine group) of 50 patients taking fluoxetine. Subjects before and after treatment for 240 cases of HAMD depression scale, HAMD depression scale seven factors, TCM symptom scores were compared and analyzed with SPSS17.0 statistical software. Results 1 sex ratio in patients with depression male: female was about 1:2, female patients significantly more than men (P lt; 0.01). Distribution of the age to 31-60 years old majority, accounting for 52%. TCM uniform distribution ratio, the syndrome did not differ significantly between. 2 syndromes with HAMD depression scale factor between 7: Patients with liver Qi stagnation in factor 3 (cognitive impairment), factor 4 (illness diurnal variation, here refers to the day and heavy night light) prominent clinical symptoms . Stagnation and spleen deficiency patients factor 2 (weight loss), factor 5 (block symptoms) clinical performance significantly. Phlegm stagnation type patients showed factor 5 (block symptoms) obvious. Heart patients with factor deficiency type 2 (weight loss) of the clinical symptoms. Patients with type kidneys do not pay a factor of three (cognitive impairment), factor 4 (illness diurnal variation, in this day and night, light weight) two factors prominent symptoms. 3 enlightened particles 1-5 fluoxetine treatment of depression and clinical efficacy (1) HAMD depression scale efficacy analysis: TCM clinical control group, significant progress, and progress was higher than western medicine group, a total clinical efficiency of traditional Chinese medicine group was 90% in the treatment group, 78%, both statistically significant (P lt; 0.01). (2) HAMD depression scale efficacy of seven factors: traditional Chinese medicine group and western medicine group in improving the factor 1, factor 5, factor 7 three factors there was no significant difference, but in the improvement factor 2, factor 3, factor 4, factor 6 four factors, the Chinese medicine group were significantly better than western medicine group (P lt; 0.01/0.05). (3) the efficacy of TCM symptom score: Medicines clinically cured, markedly effective rate higher than the western group, the total effective rate was 90.43% higher than clinical medicine group, 74%, both statistically significant (P lt; 0.01). 4 Adverse Reactions: Medicines adverse reactions was 3.16%, western medicine group incidence of adverse reactions was 14%, about four times the Medicines.
|