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Study on Polymer of Targeted Gentamicin Sulfate in Preparation and Targeting

Author: ZhuoRuYi
Tutor: SunZhiLiang
School: Hunan Agricultural University
Course: Basic Veterinary
Keywords: Targeted gentamicin sulfate Polymer Targeting Pharmacodynamics
CLC: S859.79
Type: Master's thesis
Year: 2009
Downloads: 7
Quote: 0
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Abstract


In this study, E coli Blood-serum Antibody and gentamicin sulfate were joined and prepared into the targeted supermolecule polymer of Gentamicin sulfate by polyethylene glycol (PEG6000). The suitablest temperature, acidity or alkalinity, speed to churn and the proportion of different compositions were definited by screening. The identification, verification about special targeting and validation about powerful antibacterial effect to E. coli of targeted gentamicin sulfate were done respectively by experiments of polyacrylamide gel electrophoresis(PAGE), immunofluo-rescence labeling, immunogold labeling and antibiosis in vitro.The results showed: The production of polymer was the most when Gentamicin sulfate, E.coli Blood-serum Antibody and PEG6000 were 25mg/ml, 0.1mg/ml and 15% respectively in polymer solution and when conditions were room temperature(around 25℃), PH5-6 and 800r/min.A new, posterior strap was found in the tracklane of polymer. It showed that a new polymerized production which had more molecular weight was formed.E. colis could be found on the slide which smeared by mixed solution of polymer and E. colis while no bacteria be found on the slide which smeared by mixed solution of polymer and other bacteria.Observed with electronmicroscope, the colloidal gold particles were found not only in the vacant space between bacteria but also on the cell membrane and in the cell.The results of antibacterial test against E. coli in vitro showed: the minimum inhibitory concentration of targeted gentamicin sulfate was only one twentieth of gentamicin sulfate’ s. and targeted gentamicin sulfate could sterilize completely. It showed powerful antibacterial activity.

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Veterinary Pharmacology > Veterinary drugs
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