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Effect of COX-2 Inhibitor on Expression of COX-2 and VEGF in Scalded Rats

Author: LiuHong
Tutor: XueXiaoDong
School: Lanzhou University
Course: Surgery
Keywords: Scald Wound healing Cyclooxygenase-2 Vascular endothelial growth factor Cyclooxygenase inhibitor
CLC: R644
Type: Master's thesis
Year: 2009
Downloads: 14
Quote: 0
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Abstract


AIM To observe the effect of COX-2 inhibitor on expression of COX-2 and VEGF in scalded rats.Methods 90 SD rats were randomly divided into group A,B and C. Group A was blank group（10）;Group B was simple scald control group（40）;Group C was COX-2-inhibitor treatment group（40）.Group B and C were given to anesthetize by ketamine and depilate by 10%of the sodium sulfide.Then back of rats were immersed in 90℃water for 10 seconds,and induce 20%TBSA of deepⅡdegree scaled model.Three groups were all given normal diet.Group C were given COX-2 inhibitor (Celecoxib west 0.4mg/（g.d）,day1-7).The back tissue samples of all Groups were harvested at day1,3,5,7,14 after scalded.To detect the cyclooxygenase-2（COX-2） and vascular endothelial growth factor （VEGF） expression in all samples with immunohistochemical SABC method.Results The expression of COX-2 and VEGF in group B gradually increased during day1,3,5 after scald.Group C significantly decreased than that of group B（P＜0.05）;The expression of COX-2 in group B descended at day7,14 after scald,but the expression of VEGF still ascend at same time.Compared to group B,the expression of COX-2 and VEGF in group C was significant lower.（P＜0.05） Conclusion COX-2 and VEGF play important roles in wound healing.COX-2 inhibitors could significantly inhibit the expression of COX-2,VEGF in scald tissue,

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CLC: > Medicine, health > Surgery > Traumatology > Burns and scalds ( burns )
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