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Effect of Electro-acupuncturing (EA) the Points of Yangming Meridian of Foot on the Expression of EGF and EGFR in Rats with the Lesion of Gastric Mucosa

Author: HuangAi
Tutor: YangRenDa
School: Hunan University of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: Electro-acupuncture Meridian Gastric mucosal injury EGF EGFR
CLC: R245
Type: Master's thesis
Year: 2006
Downloads: 13
Quote: 0
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Abstract


Objective: To investigate the foot Yangming stomach specificity and Yangming Meridian on gastric mucosal injury in pre possible mechanisms of the protective effect . Methods : 40 rats were randomly divided into blank group , model group , Yangming Meridian group ( stomach meridian group ) , the EA enough the Shaoyang Meridian group ( Gallbladder group ) , immersion restraint law made mode , after the end of the experiment, the detection of gastric mucosal damage index ( UI ) and observed under light microscope mucosal morphology changes , the detection of gastric mucosal blood flow ( GMBF) , the serum and gastric mucosa , epidermal growth factor was measured by radioimmunoassay ( EGF) content , and the determination of the expression of the epidermal growth factor receptor (EGFR) immunohistochemistry . Results: ( 1) EA group can gastric mucosal injury index was significantly reduced gastric mucosal blood flow , increased gastric mucosal tissue and serum EGF content in which the strongest stomach by the group role and gall bladder group have a very significant difference ( P lt; 0.01 ) . EGFR expression ( 2) EA and model of gastric mucosa enhanced, but groups showed no significant difference ( P gt ; 0.05 ), may be related to the observation time is too short . Conclusions : ( 1) Yangming Meridian on gastric mucosal injury really obvious pre - protective effect . (2) Yangming Meridian by improving the GMBF the ways to participate in the pre - protective effect of the gastric mucosa . ( 3 ) promote the synthesis , secretion and expression of EGF, EGFR and other related protective factors may be electrically pre - protective effect against gastric mucosal injury is one important way (4) Meridian and stomach relative correlation .

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