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Common TCM syndrome and serum homocysteine ??and diastolic function relationships of the newly diagnosed patients with type 2 diabetes

Author: BaiSong
Tutor: GaoTianShu
School: Liaoning University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: diabetes disturbance of the spleen due to damp-heat subclinical hypothyroidism blood lipid homocysteine diastolic function
CLC: R259
Type: Master's thesis
Year: 2011
Downloads: 3
Quote: 0
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Abstract


Objective:Study on the change of the blood lipid, homocysteine and diastolic function when the diabetes combined with subclinical hypothyroidism of common Traditional Chinese Medicine syndrome type, to understand the relationship between the subclinical hypothyroidism and the atherosclerosis. The effect of subclinical hypothyroidism on the diastolic function also investigated. This study would provide theoretical basis for intervention treatment of the patients with disturbance of the spleen due to damp-heat diabetes combined with subclinical hypothyroidism.Method:Collected in Endocrine Department of Shenzhou hospital inpatient or outpatient endocrinology diabetes in patients with disturbance of the spleen due to damp-heat diabetes combined with subclinical hypothyroidism(DSDH group) and diabetes but with normal thyroid function (Impairment of both QI and YIN, IBQY group) cases for each 20 cases. At the same time, 20 persons were selected from community residents without diabetes and normal thyroid function as a control group. The thyroid function (FT3, FT4, TSH), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum triglyceride (TG), total Cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum homocysteine (Hcy) and cardiac ultrasonography were tested. Test results were statistical analysized and established the relationship between the indicators and interaction mechanisms.Results:1.Serum TSH level of DSDH group were significantly higher than the control group and IBQY group (P<0.05), there was significant difference. There was no significant difference of the FT3 and FT4 (P>0.05). FPG and HbA1c levels of DSDH group and IBQY group were significantly higher than the control group (P<0.05), but there was no significant difference between DSDH group and IBQY group (P>0.05).2.Plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), serum triglyceride (TG) of DSDH group and IBQY group were higher than the control group, but high-density lipoprotein cholesterol (HDL-C) was lower (P<0.05), there was significant difference. And the TC、TG、LDL-C level was no significant difference between two groups (P>0.05) although the levels of DSDH group were a little higher. Serum homocysteine (Hcy) of DSDH group was higher than the IBQY group and control group, there was significant difference (P<0.05). And the Hcy level of IBQY group was a little higher than the control group, but two groups was no significant difference (P>0.05).3.Em, Am and Em / Am values of DSDH group and IBQY group were significant lower than the control group (P<0.05). And Em, Am and Em / Am values of DSDH group were reduced slightly compared with IBQY group, but there was no significant difference (P>0.05).Conclusions:1.Remarkable dyslipidemia and diastolic dysfunction are accompanied with impairment of both QI and YIN and disturbance of the spleen due to damp-heat.2.Homocysteine level of DSDH group is significantly increased suggestting that this type of patients more susceptible to atherosclerosis. Intervention treatment should be carried out at early stage.

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