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In this paper, the non-aqueous polar media microemulsion systems were prepared by using poly(4) glycerol mono alkyl ether(PGL), isopropyl palmitate(IPP), isopropyl isotearate (IPI), glycerol(GY), propylene glycol(PG),1,3-butylene glycol(BG), symdiol 68(the mixture of 65% 1,2-hexylenediol and 35% 1,2-octylenediol); and its phase behavior was investigated. The effects of polar media, temperature, the ratio of surfactant and co-surfactant and the addition of vitamin C (Vc) on the phase behavior were investigated. The temperature resistance, rheological behaviour, viscosity property of non-aqueous microemulsion systems, the retention rate of Vc in non-aqueous polar media microemulsion systems and animal skin safety experiment were also investigated. The main conclusions were made as follows:1) The six non-aqueous microemulsion systems of GY, PG, BG/PGL/S68/IPP and GY, PG, BG/PGL/S68/IPI and their phase diagrams could be obtained by using PGL as main emulsifier, S68 as assistant emulsifier, IPP and IPI as oil phase, GY, PG and BG as non-aqueous polar media respectively. The results of phase behavior showed that the effects of different polar media on the microemulsion area were not significant, and the microemulsion area of microemulsion systems containing glycerol was greater than others. The increases of temperature and the content of S68 could both increase the microemulsion area.2) The six systems of GY, PG, BG/PGL/S68/IPP/Vc and GY, PG, BG/PGL/S68/IPI/Vc and their phase diagrams could be obtained on the base of these six non-aqueous microemulsion systems. The influence of Vc on the microemusified zone in phase diagram was insignificant. The GY/PGL/S68/IPI non-aqueous microemulsion system which was stable at -4℃and 48℃could be obtained.3) The results of rheological behavior research showed that the non-aqueous microemulsion systems of GY/PGL/S68/IPP and GY/PGL/S68/IPI belonged to Newtonian fluid. The viscosity of the non-aqueous microemulsion systems decreased with increase of oil content and it increased with the addition of Vc.4) The retention rate of Vc could reach more than 90% in non-aqueous microemulsion systems of GY/PGL/S68/IPP/Vc and GY/PGL/S68/IPI/Vc, showing good stability of Vc. The animal skin safety in the formula containing Vc was illustrated further. The study in this paper is expected to provide new carriers for the stablility of Vitamin C and be applied to develop novel cosmetic products of whitening and anti-aging.
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