Dissertation > Excellent graduate degree dissertation topics show

Homoisoflavonoids from Ophiopogon Japonicus and Alkaloids from Elaeocarpus Sphaericus

Author: WangXueYao
Tutor: ZhouChangXin;GanLiShe
School: Zhejiang University
Course: Of Pharmacy
Keywords: Ophiopogon japonicus Elaeocarpus sphaericus homoisoflavonoids alkaloids
CLC: R284.1
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
Read: Download Dissertation

Abstract


The dry root tuber of Ophiopogon japonicus (L.f.) Ker-Gawl.(Liliaceae) is one of the most important Triditional Chinese Medicine. Elaeocarpus sphaericus (Gaertn.) K. Schum. (Elaeocarpaceae) is a tall tree growing in tropical areas of China.The 95%ethanol extract of O. japonicus and E. sphaericus were studied respectively. On the basis of modern chromatography isolation techniques and spectroscopic structure identification methods, thirteen homoisoflavonoids were isolated with their structures identified from O. japonicus, including 8-Formyl-7-hydroxy-5,4’-dimethoxy-6-methylhomoisoflavone (1). 6-Aldehydoisoophiopogonone B (2), Ophiopogonone C(3), Methylophiopogonone B Monomethyl Ether(4),8-Formylophiopogonone B(5), Ophiopogonanone B(6), 5,7,4’-Trihydroxy-3’-methoxy-6,8-dimethylhomoisoflavanone(7), Methylophiopogonanone B(8), Methylophiopogonanone A(9), 8-Formyl-7-hydroxy-5,4’-dimethoxy-6-methylhomoisoflavanone (10), 8-Formylophiopogonanone B(11), Methylophiopogonanone B Monomethyl Ether (12),8-Formylophiopogonanone A(13). Among these homoisoflavonoids, compounds 1,2 and 11 are new compounds. The NMR data of compounds 10 was first reported here and compounds 5 in previous literature were reassigned definitely by 2D NMR experiments.Meanwhile,the cytoprotection activities of the above 13 compounds were assayed based on H9C2 cell which was is chemic and hypoxic.Five indolizidine alkaloids were isolated from E. sphaericus. Their structures were determined as (±)-3-oxo-isoelaeocarpine(14), (±)-elaeocarpine-N-oxide (15), (±)-isoelaeocarpine (16), (±)-elaeocarpine (17) and (-)-isoelaeocarpiline (18) by physicochemical propertiesand spectral data. Compounds 14 and 15 are new compounds. Enantiomers of compounds 14 and 16 were separated on a chiral CD-Ph column and determined by TDDFT quantum chemical calculations of their ECD spectra. In conclusion, the current study has provided rational and experimental basis for further development of these plants and their quality control.

Related Dissertations

  1. Dark purple Fritillaria medicinal active ingredient extraction technology and the chemical composition of,TQ461
  2. Study on Extraction and Antioxidant Activity of Antioxidant Active Substances from Oat,TS201
  3. Study on the Preparation and the Quality Standards of the Wuhuo Depressurization Dripping Pills,TQ461
  4. High pressure steaming aconite in ester alkaloids in variation research,TQ464.4
  5. Phenolic Alkaloids of Menispermum Dauricum Transdermal Drug Delivery in Vitro,R285
  6. Research on Quality Control Methods of Ophiopogonis Radix and Seedling,R284
  7. Extraction and Separation of Alkaloids in Aconitum Herbs and Studies of ESI-MS~n on Aconitine-type Alkalaids,R284
  8. Study on the Alkaloids and Their Antimicrobial Activity of the Aerial Part of Hypecoum Erectum L.,S567.219
  9. Studies on Environmental Behavior of Alkaloids from Tripterygiun Wilfordii Hook.F.,S482.3
  10. Study of Chemical Constituents of Aconitum Handelianum Comber and the Structure Modification of Diterpenoid Alkaloids,R284
  11. The Effect of PAMD on the Expression of COX-2 and VEGF of the S180 Tumour-Bearing Mice,R285.5
  12. The Research on the Effect of Hyaluronic Acid Nuxvomica Total Alkaloids Joint Cavity Gel Injection on the Experimental Knee Osteoarthritis Rat,R684.3
  13. Chemical Constituents of the Aerial Parts of Cynanchum Chinense R.Br,R284.1
  14. Effects of Alkaloids of Sophora on Motor Function of Guinea Pigs Gallbladder in Vitro and in Vivo,R285.5
  15. Synergetic Effects of Rhynchophylla Total Alkaloids and Gastrodin on Antihypertension and Target Organs Protection,R285
  16. Studies on Alkaloids of Sophora Flavescens for Injection,R283
  17. Study on the Method of Quality Control of Sheng Mai Powder for Injection,R286
  18. Baikal Thalictrum and chemical constituents of Gentiana macrophylla,R284
  19. Study on the Total Synthesis of β-Carboline Alkaloids DichotomineA-B and Technics of Pendimethalin,R284
  20. Study on Diversity and Evaluate of the Quality of Traditional Chinese Medicine Fritillaria,R282.7

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical > Chemical analysis and identification
© 2012 www.DissertationTopic.Net  Mobile