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5'- guanylate , disodium is a nucleotide compounds is commonly used in food fresheners . Domestic product in terms of purity , crystal size and crystalline form with similar foreign products , there is a big gap , thus at a disadvantage in international competition in the market . To solve these problems , disodium 5'- guanylate crystallization process system . In this paper, the gravimetric determination of disodium 5'- guanylate solubility in water - ethanol system , the effects of pH , solvent ratio , the influence of temperature on the solubility and solubility data associated using Apelblat equation . Disodium 5'- guanylate ultra solubility in water - ethanol system , the effects of pH , solvent ratio, temperature solubility turbidimetric assay using Apelblat equation fitting the data . Comprehensive analysis of different pH, solvent ratio , temperature conditions , the solubility and solubility changes and metastable zone trends scenario . In this paper, the anti- solvent crystallization method , three 5'- guanylate , disodium raw crystallization process . By single factor experiment investigated the impact factors of disodium 5'- guanylate crystallization process . Reference the food additive 5' -guanylic acid disodium Test Method QB / T 2846-2007 to GMP crystalline product detection , and using a microscope recording and analysis of the polymorph , and identified under the preferred crystallization process conditions in the different raw materials . Finally, using the the FBRM line analysis technology , combined with the process of crystal -type analysis examines the 5'- guanylate , disodium anti - solvent crystallization through the CRYSTALLIZATION type conversion and yield control factors . This paper can provide a useful reference for the 5'- guanylate , disodium anti- solvent crystallization process .
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