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Study on Properties and Release Behavior of Konjac Glucomannan/xanthan Gum Plural Gel for Drug Carrier

Author: WeiZuoHua
Tutor: LiGuangJi
School: South China University of Technology
Course: Polymer Chemistry and Physics
Keywords: Glucomannan (KGM) Xanthan gum (XG) Composite gel Urea Levodopa (L-Dopa) 4 - aminosalicylic acid (4-ASA) Release
CLC: TQ460.1
Type: Master's thesis
Year: 2010
Downloads: 239
Quote: 1
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Abstract


Konjac glucomannan (KGM) and xanthan gum (XG) are rich sources of renewable natural polysaccharide, has been widely used as a food or food additives used in food industry. They have excellent biocompatibility and biodegradability, degradation products are not harmful to humans and the environment. Studies have found, KGM and XG there is a strong synergy between the two form a composite gel viscosity and gel strength than the same concentration is much stronger single gel; KGM after are not present on the digestive tract in the stomach and small intestine enzymes degraded parts only when it reaches the colon after being present in the colon enzymatic degradation of β-mannose, and XG is not in the human digestive enzymes degrade. These properties give the KGM / XG composite gel as a slow-release fertilizer and oral drug carrier excellent basic characteristics. Therefore, the design and preparation with a suitable gel strength and swelling characteristics of KGM / XG composite gel, research as fertilizers and oral drug release characteristics when the carrier has important significance and broad application prospects. In this study, a total concentration of the polysaccharide 0.2 ~ 2 wt% range, to prepare a series of different KGM / XG mass ratio of the composite gel, using texture test (TPA) and rheological testing (RDA) of the composite gel The gel strength was characterized to determine the total concentration of the polysaccharide was 1%, KGM / XG mass ratio of 1:1 to prepare the composite gel can exhibit strong synergistic effect, the gel strength, the three-dimensional network structure to a certain pressure and temperature range remained relatively stable. Right KGM / XG composite gel under different conditions, studies have shown that the swelling behavior: The swelling behavior of the composite has significant pH sensitivity. At pH? 6.0 acidic environment, the swelling will be inhibited; When the pH is in the range of 6.0 to 8.0, the equilibrium swelling ratio of the gel compound as the pH increases significantly increased, and the pH value 8.0 maximum. Based on these results, the largest amount of nitrogen in urea, anti-Parkinson drugs levodopa (L-Dopa) and a drug used to treat ulcerative colitis 4 - aminosalicylic acid (4-ASA) as a model drug, respectively, prepared by embedding urea, L-Dopa and 4-ASA drug loading KGM / XG gel system, study its basic nature and at different temperatures and pH environment of the release characteristics and mechanism. The results show that: (a) urea embedded KGM / XG composite gel having similar drug-free composite gel strength and rheological properties of a gel; embedded L-Dopa and 4-ASA in KGM / XG compound gel due to L-Dopa or 4-ASA and the hydrogen bonding between polysaccharide macromolecules and crosslinking of the gel showed a higher strength and lower equilibrium swelling degree, when the drug reaches 25.0 mg / g when This effect is particularly obvious. This effect is beneficial to inhibit the proliferation of drug release gel to achieve sustained and controlled release of drugs. (B) embedding urea KGM / XG composite gel in a neutral aqueous medium, the release of urea from the composite gel mainly controlled swelling behavior. Elevated temperatures will accelerate the disintegration of composite gel, thereby increasing the release rate of urea and cumulative release rate. Embedded urea release behavior of composite gel has obvious pH sensitivity. In alkaline conditions, at 50 h the release process, accelerating the release rate of urea, the cumulative release rate was significantly increased; pH 2.0 at 50 h of urea cumulative release rate was 11.8%, the release curve gentle. Thus, in the more acidic conditions, urea embedded KGM / XG composite gel can be achieved within a relatively long period of time release. (C) embedding L-Dopa of KGM / XG composite gels and embedded 4-ASA of KGM / XG composite gel drug delivery has significant pH sensitivity. Both at pH 1.0 simulated human gastric juice, 3 h cumulative release rate of the drug within the lower were only 13.21% and 7.38%; at pH 6.8 and 7.4 simulated human intestinal fluid, 24 h within the L-Dopa The cumulative release rates were 53.53% and 76.62% ,4-ASA cumulative release rates were 63.00% and 68.04%. Thus, KGM / XG composite gel as an oral L-Dopa and 4-ASA drug carrier can reduce drug \target delivery purposes. (D) respectively, using the embedded Peppas equation L-Dopa, and drug loading of 4-ASA KGM / XG composite gel at different pH environments release curve fitting analysis were found in the pH range tested, L -Dopa release fitting curve theory and experimental curves are similar, the release parameter n? 0.45, Description L-Dopa from KGM / XG composite gel release followed Fickian diffusion mechanism; at pH 1.0 and 6.8 media, four - ASA released theoretical and experimental curve fitting curve is also similar, the release parameter n were 0.3307 and 0.3959,4-ASA release also follows Fickian diffusion mechanism; while the medium at pH 7.4, n is the value 0.5848, indicating that in this a condition ,4-ASA release by diffusion and erosion matrix composite gel jointly controlled drug delivery.

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