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Telmisartan and rosiglitazone in diabetic rats early atherosclerosis formation

Author: LiZuo
Tutor: ChenZuoYuan
School: Qingdao University
Course: Internal Medicine
Keywords: Type 2 diabetes Atherosclerosis Telmisartan Rosiglitazone
CLC: R543
Type: Master's thesis
Year: 2010
Downloads: 43
Quote: 0
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Abstract


Background and purpose of type 2 diabetes with macrovascular disease is the most common chronic complication of diabetes is also disabled, and cause of death. Vascular atherosclerosis in type 2 diabetes, which is the pathological basis of macrovascular disease, but also accelerate the generation of diabetic macrovascular important factor. Meanwhile, diabetes as an independent risk factor, but also on vascular atherosclerosis accelerate the occurrence and development play a role, including vascular endothelial cell damage is the occurrence of atherosclerosis is an important initial link. Prevention and treatment of cardiovascular and cerebrovascular diseases, and anti-atherosclerosis drug application, has a very important significance. In this study, through the establishment and human atherosclerosis formation and pathological characteristics were similar in rat model of atherosclerosis, type 2 diabetic rats was observed early formation of atherosclerosis, aortic wall peroxisome proliferator-activated receptor-γ and vascular cell adhesion molecule-1, cell adhesion molecule-1 expression and subendothelial infiltration of mononuclear cells, and to explore angiotensin Ⅱ 1 receptor antagonist telmisartan and thiazolidinedione TZDs rosiglitazone in type 2 diabetic rats with early atherosclerosis formation, and to explore its possible mechanism. Methods 40 male rats of clean grade were randomly divided into four groups, A group of normal control group, B group of type 2 diabetes group, C group of telmisartan group, D group rosiglitazone group, each group 10. B, C, D groups making use of high sugar high fat diet diabetic rats model of early atherosclerosis, all rats were divided equally by the cage clean grade animal feed, the test period is 16 weeks. After 16 weeks, respectively, and serum total cholesterol, triglycerides, low-density lipoprotein cholesterol and blood sugar steady, steady-state concentrations of insulin; immunohistochemical assay aortic wall of peroxisome proliferator-activated receptor - γ and vascular cell adhesion molecule-1, cell adhesion molecule-1 expression and endothelial monocyte infiltration number changes. Result of type 2 diabetes group, the telmisartan group and rosiglitazone group serum total cholesterol, triglycerides, low-density lipoprotein cholesterol and blood sugar levels steady state compared with normal control group was significantly higher (P <0.05); for telmisartan group and rosiglitazone group, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol and blood sugar levels steady state were decreased compared with type 2 diabetes, and there is a significant difference (P <0.05). Type 2 diabetes, telmisartan and rosiglitazone group aortic wall peroxisome proliferator-activated receptor-Y, vascular cell adhesion molecule-1, cell adhesion molecule-1 expression was significantly higher than the normal control group (P <0.05), but the type 2 diabetes group, the telmisartan group and rosiglitazone group between the vessel wall peroxisome proliferator-activated receptor-Y no significant difference (P> 0.05) ; telmisartan group and rosiglitazone group vascular cell adhesion molecule-1, cell adhesion molecule-1 expression was significantly lower than the type 2 diabetes group (P <0.05) Conclusion telmisartan and rosiglitazone can enhance vascular wall peroxisome proliferator-activated receptor-γ activation, inhibition of vascular cell adhesion molecule-1, cell adhesion molecule-1 expression and mononuclear cell infiltration, prevent early formation of AS.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Vascular disease
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