Dissertation > Excellent graduate degree dissertation topics show

Molecular Dynamics Study on Neural Coding of Auditory

Author: WeiHeng
Tutor: WangRuBin
School: East China University of Science and Technology
Course: Control Science and Engineering
Keywords: basilar membrane vibration outer hair cell electromotility delay effect electro-dif-fusion model
CLC: R764
Type: Master's thesis
Year: 2012
Downloads: 22
Quote: 0
Read: Download Dissertation


Basilar membrane vibration in the Cochlea is important for the frequency and intensity discrimination of sound.Previous models for basilar membrane vibration doesn’t take into account the influences caused by different speeds(i.e.,delay effect) of outer hair cells own motion(i.e.,OHC electromotility),and can’t comprehensively describe the active effect of OHC in the basilar membrane vibration.Therefore,we introduce a new model,which includes the delay effect of OHC electromotility.According to the simulations,the new model complies with physiological features of OHC electromotility and illustrates a novel comprehe -nsion of the contribution of OHC electromotility on basilar membrane vibration.Membrane protein Prestin is the key component of OHC electromotility,and crucial to the Cochlea amplification and frequency selectivity of the mammalian ear.The Prestin performance is critically dependent on chloride ions,and intrinsic protein charges also play a role.To research the frequency and voltage dependence of electric charge (i.e.,anion and protein charges)transfer by Prestin when the applied electric field exists,We introduce an new electro-diffusion model.This model uses a Fokker-Planck equation to describe the kinetics of the translocated charge.The results from this model are consistent with experimental observations,and are important for further analysis of the structure and function of Prestin.

Related Dissertations

  1. Design and Research of Control System in Three Phase Shunt Active Power Filter,TN713.8
  2. An Empirical Study on Disclosure Quality and Corporate Performance,F224
  3. Noninvasive limb ischemic preconditioning on myocardial ischemia and reperfusion in rats aged injury in rats,R542.22
  4. PWM digital power modeling,TM46
  5. Coupling Model for Basilar Membrane with Delay Action,R764
  6. The Changes of Correlation Audiology and Cochlea’s Function in an Animal Model of Cerebral Concussion: An Experimental Study,R764
  7. Effect of Iron Deficiency on Distortion Product Otoacoustic Emissions: An Experimental Study,R764
  8. The Road Subsidence Monitoring Based on Coherent Target DInSAR Technique in South of China,P642.26
  9. Effectiveness of Monetary Policy,F822.0
  10. Fabrication, Microstructure and Mechanical Behavior of Functionally-Graded SiC Particulates Reinforced Al Matrix Composites,TB331
  11. Regulatory Roles of the Cochlear Redox Status in Hair Cell Decision to Die by Apoptosis or Necrosis Following Exposure to Intense Noise,R764
  12. Study on Hearing Loss Induced by Co-administration of Kanamycin with Furosemide and Gene Therapy in Guinea Pigs,R764.43
  13. The Study on the Vestibular 3d Reconstruction of Guinea Pig and the Numerical Simulation of Temperature Field,R764
  14. The Role of BimEL in the Pathogenesis of the Ototoxicity Induced by Cisplatin,R764
  15. Acoustics-Structure Coupled Analysis and Its Application in Simulation of Sound Transmission in Ear,R764
  16. The Reconstruction and Validation of the Human External Acoustic Meatus and Middle Ear Finite Element Model,R764
  17. Assessment to the Effect of Hearing Aid Fitting of Presbycusis,R764
  18. The Study of Subjective Visual Horizontal in Peripheral Unilateral Vestibular Dysfunction,R764.04
  19. Experimental Autoimmune Meniere’s Disease Induced by Immunization with Four Kind of Components Pured from Inner Ear Membranous Labyrinth Tissue in Guinea Pig,R764
  20. Changes in Histamine H2, H3 Receptor Expression in Rat Medial Vestibular Nucleus and Flocculus after Unilateral Labyrinthectomy,R764
  21. Design, Organization and Implementation of Otology Epidemiological Survey among Middle School Students,R764
  22. Oral Korea red ginseng on the tympanic membrane caused by injection of gentamicin ear vestibular function and hearing function Injury,R764

CLC: > Medicine, health > Otorhinolaryngology > Otology,ear disease
© 2012 www.DissertationTopic.Net  Mobile