Dissertation > Excellent graduate degree dissertation topics show

Effect of Intraoperative Interorganizational Injection Chemotherapy Targeted on Ki-67, Apoptosis in Metastatic Lymph Nodes of Advanced Gastric Carcinoma

Author: XuXueFeng
Tutor: JiangHuaiWu
School: Luzhou Medical College
Course: Surgery
Keywords: Advanced gastric cancer Targeted chemotherapy Ki-67 gene Apoptosis
CLC: R735.2
Type: Master's thesis
Year: 2010
Downloads: 56
Quote: 0
Read: Download Dissertation

Abstract


Objective: To understand the injection targeted chemotherapy transfer lymph Ki-67 expression and apoptosis (apoptosis, AI) , explore the treatment of advanced gastric cancer surgery to strengthen the effectiveness of advanced gastric cancer surgery organization . Methods : Radical preoperative cut stomach No. 3 No.6 or No.7 lymph nodes in a rapid frozen section confirmed as metastatic cancer patients included in the study , to meet the requirements of 28 patients with advanced gastric cancer were randomly divided into two groups direct surgical control group ( treatment group and the control group ) , the treatment group in the tumor tissue and surrounding injection of methylene blue and mitomycin mixture ( of methylene blue 2ml mitomycin 8mg0.9 % NS20m1 ) after surgery, . Surgery take metastatic lymph nodes with 4% paraformaldehyde fixed , paraffin-embedded , HE staining , each group select 20 of metastatic lymph nodes (treatment group were selected staining ) prepared for the study . Specimens (including the radical former specimens ) the effectiveness of observation and ki-67 expression, apoptosis detection . Results: Before treatment, the transfer of lymph node tumor apoptosis and necrosis of the validity of the difference was not statistically significance ( P gt ; 0.05 ); before treatment of metastatic lymph nodes ki-67 expression , apoptosis index was no statistical difference ( P gt ; 0.05) ; after treatment, the metastatic lymph node tumor cell apoptosis , necrosis of the validity of ( rate ) than control group , the difference was statistically significant (P lt; 0.05); after treatment, the transfer of lymph node Ki-67 expression positive rate is lower than before treatment , the apoptotic index is higher than before treatment , before and after differences with statistical significance ( P lt ; 0.05 ); after treatment, the metastatic lymph nodes Ki-67 expression is lower than that of the control group , the apoptotic index higher than that in control group , the difference between the two groups was statistically significant (P lt; 0.05) Conclusion: The inter-organizational injection targeted chemotherapy can inhibit metastasis of gastric cancer lymph node tumor cell proliferation and promote apoptosis of tumor cells have a direct role in the treatment of lymph node metastasis stove ; organization targeted injection of chemotherapy treatment is an effective technique to strengthen , to prevent iatrogenic proliferation micrometastases , micro - residue and postoperative recurrence and metastasis may have a certain effect .

Related Dissertations

  1. The Study on Cryopreservation and Mechanism of Freezing Injury on the Spermatozoa of Coelomactra Antiquate,S968.3
  2. The Apoptosis Mechanism Induced by Aflatoxin B1 and Deoxynivalenol in Primary Hepatocyte of Cyprinus Carpio,S856.9
  3. The Signal Mechanism Underlying DON Induced Apoptosis in BHK-21 Cells,S856.9
  4. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3
  5. The Study of Mitochondrial Signal Mechanism Induced Apoptosis by Don in Human Colon Cancer Cells,R735.35
  6. The Impact of Histone Deacetylase Inhibitor Trichostatin a on Proliferation and Apoptosis of Porcine Granulosa Cells,S828
  7. Effects of Elemene on Topoisomerase Ⅰ Andⅱof Human Hepatocarcinoma HepG-2 Cells,R735.7
  8. Inhibitory Role of Plasmodium Yoelii Circumsporozoite Protein on the Proliferation and Survial of Tumor Cell,R730.5
  9. Effects of Different Immunization on the Development of Immune Organs,cell Proliferation and Expression of Apoptosis-relatived Gene in Chicken,S858.31
  10. Effect of Bufalin on Proliferation and Induce Apoptosis of Vascular Endothelial Cells EAhy926,R285
  11. Induction of Apoptosis by d-limonene is Mediated by Mitochondrial Death Pathway in Human Leukemia Cells,R733.7
  12. Effect of Esculentoside a on Apoptosis and Expression of PCNA、Caspase-3、Fas and FasL in Renal Tissue of BXSB Mice,R285.5
  13. The Effect of Bidentata Saponins on Early Osteoarthritis in Rabbit and PI3K/AKT Pathway,R285.5
  14. Effects of Dachengqi Decoction on the Expression Levels of Bcl-2 and Bax Gene of Smooth Muscle Cells of Small Intestine in Rat with Multiple Organ Dysfunction Syndrome,R285.5
  15. Effect of Hypoxic Postconditioning on Alveolar Epithelial Type Ⅱ Cell Mitochondrial Apoptotic Pathway,R563.8
  16. The Relevance Research of Neuroglobin and Caspase-3 in the Hippocampus CA1 Regin in Global Cerebral Ischemia-reperfused Rats,R741
  17. Gulf War syndrome in rats hippocampal neuronal apoptosis and Omi/HtrA2, Smac expression,R82
  18. Effects of Rpb5-mediating Protein (RMP) on Cell Proliferation of Hepatocellular Carcinoma Cells,R735.7
  19. The Study on the Radiosensitizing Effect of Artesunate on Nude Mouse Transplanted with HeLa and Siha Cells of Cervical Cancer,R737.33
  20. Radiosensitizing Effect of Cathepsin L on Glioma Stem Cells,R739.4
  21. The Experimental Study of Radiofrequency Ablation Combined with Percutaneous Ethanol Injection in Vivo Rabbit Liver,R817.5

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
© 2012 www.DissertationTopic.Net  Mobile