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Objective: evaluation of high epidural anesthesia (Thoracic epidural anesthesia, TEA) plasma endothelin (Endothelin, ET) intraoperative anesthesia , discussion epidural blockade in general anesthesia , myocardial protection , in order to high epidural anesthesia in clinical application and promotion as a reference. Methods: The the computer retrieval Chinese journals full-text database . , VIP , Pubmed , EMCC , and manual searches and collect high epidural anesthesia and endothelin literature to develop inclusion and exclusion criteria , screening literature . Collect the literature relevant information , tabulation , and evaluation of quality literature , rated using jadad scoring criteria , changes in the amount of endothelin in the statistical literature , measurement data material with a weighted mean difference (WMD) and 95% confidence interval . The Revman 4.2.2 software , the statistical analysis completed , draw forest plot and funnel plot analysis impartiality and heterogeneity . Results : meet the standard literature 9 , 313 of the patients , the analysis shows that high epidural anesthesia combined with general anesthesia and anesthesia alone compared to surgery in patients with postoperative plasma endothelin levels can reduce [WMD = -210.41:95 % CI ( -22.80 , -18.03 ) , test for heterogeneity P = 0.10 , heterogeneity using a fixed effect model . Conclusion: The high epidural anesthesia to general anesthesia the patient can significantly reduce endothelin levels .
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