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Study on the Intestinal Mucosa Pathology and the Secretion Level of TNF-a, IL-8 in the Chronic Non-Specific Ulcerative Colitis with Dampness Heat Syndrome

Author: XuShaoLian
Tutor: ChenJinFang
School: Fujian University of Traditional Chinese Medicine
Course: Clinical basis for TCM
Keywords: Colitis Ulcerative/Pathology Intestinal Mucosa/Pathology Dampness Heat/Pathology Liver Qi Stagnation and Spleen Deficiency/Pathology Tumor Necrosis Factor-alpha/Secrete Interleukin-8/Secrete
CLC: R259
Type: Master's thesis
Year: 2010
Downloads: 111
Quote: 0
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Abstract


Objective:Through the observation of chronic nonspecific ulcerative colitis Damp-heat Syndrome pathological changes of colonic mucosa, intestinal secretion of Tumor Necrosis Factor-alpha(TNF-a), Interleukin-8 (IL-8) levels of patients the disease physical, immunological basis, provide the theoretical basis for clinical treatment.Method:Chooses the Chronic Non-Specificity Ulcerous Colitis patient sixty examples, after dialectical is the gathering of Dampness Heat Syndrome card thirty examples (study team), the Liver Qi Stagnation and Spleen Deficiency card thirty examples (control group), conducts the comparison research. All subjects underwent colonoscopy examination, observes the intestines mucous membrane pathological change situation; And takes the mucous membrane biopsy specimen,carries on the pathology diagnosis and TNF-a, the IL-8 secretion level examination.Results:1. Different enteroscopy images:Dampness Heat Syndrome Colonic mucosa showed rough surface mirror, congestive erosion significantly, bloody mucus secretion increased lumen dirty, disease extent wide, and even the entire colon can be involved; Liver Qi Stagnation and Spleen Deficiency showed evidence of colonic mucosal surface of the mirror color pale, vascular reticulate disarray, and the mucous membrane brittleness, secretions thin; Dampness Heat Syndrome group colonoscopy mucosal lesions compared with the Liver Qi Stagnation and Spleen Deficiency group was significantly different (P<0.05).2. Pathological changes:Dampness Heat Syndrome group erosion and ulceration of serious colon mucosa, a large number of infiltrating inflammatory cells, goblet cells decreased, crypt disorder, distorted; Liver Qi Stagnation and Spleen Deficiency group erosion and ulceration of colonic mucosa minor, a small amount of scattered mucosal inflammatory cell infiltration, goblet cells have not been significantly reduced; with Liver Qi Stagnation and Spleen Deficiency were significantly different(P<0.05).3. Intestinal mucosa secrete TNF-a, IL-8 secretion levels:Dampness Heat Syndrome intestinal mucosa secrete TNF-a, IL-8 levels were significantly increased, and the more severe the disease the higher the level of, secretion (P<0.05), and Liver Qi Stagnation and Spleen Deficiency there was a significant group difference(P<0.05). Conclusion:1. Chronic Non-Specific Ulcerative Colitis’s Syndrome of Dampness Heat more serious intestinal diseases, chronic inflammation in the acute stage.2. Chronic Non-Specific Ulcerative Colitis with Dampness Heat Syndrome secretion of intestinal TNF-a, IL-8 levels were significantly higher than Liver Qi Stagnation and Spleen Deficiency. Tip TNF-a, IL-8 in the large intestine Dampness Heat Syndrome in the pathological changes of intrinsic permit may play an important role.

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