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Clinical Observation and Mechanism on Knee Osteoarthritis with Bushen Huoxue Decoction

Author: PanXiGui
Tutor: XiuZhongBiao
School: Fujian University of Traditional Chinese Medicine
Course: TCM orthopedics and traumatology
Keywords: Knee Osteoarthritis Bushen Huoxue Decoction Clinical Obscrvation Mechanism
CLC: R274.9
Type: Master's thesis
Year: 2010
Downloads: 95
Quote: 0
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Abstract


Objective:To observe the therapeutic effect and the levels of nitric oxide (NO), interleukin-1β(IL-1β), transforming growth factorβ1 (TGF-β1) in synovial fluid before and after treatment on knee osteoarthritis(OA) with Bushen Huoxue decoction, we investigated the further mechanism by tonifying kidney and invigorating the circulation of blood for the knee osteoarthritis using prospective study and statistics methods.Methods:Object of study for the Orthopedic outpatient patients, according to knee osteoarthritis in the Western diagnostic criteria, inclusion criteria and exclusion criteria into kidney deficiency and blood stasis-type osteoarthritis of the knee.30 patients taking the benefits to Bushen Huoxue Decoction, continuous treatment of 2 courses (6 weeks) were observed before and after treatment in patients with Lysholm knee score situation, X-ray changes and adverse reactions. Laboratory testing of indicators in accordance with the provisions required in the treatment before and after treatment, respectively, synovial fluid extraction (-20℃cold storage), using colorimetric detection of NO, double-antibody sandwich assay IL-1β, TGF-β1, the data used SPSS13.0 for Windows software for statistical analysis.Results:Lysholm knee score showed an upward trend, the patient knee symptoms, signs and knee function were significantly improved,X-ray film before and after treatment showed no significant changes and found no adverse reaction; the levels of NO and IL-1βwere significantly decreased, TGF-β1 were significantly higher after a course of treatment; the levels of NO and IL-1βwere continued to decline and TGF-β1 continue to rise on average after two courses of treatment.Conclusion:Bushen Huoxue Decoction can improve knee osteoarthritis in patients with clinical symptoms, signs and knee function; lower the levels of NO, IL-1β, increased the levels of TGF-β1 in synovial fluid. it may be inferred that the levels of IL-1β, NO, TGF-β1 are related to the pathogenesis of osteoarthritis. In a certain extent, Bushen Huoxue Decoction may take effect by affecting the levels on IL-1β, NO and TGF-β1 in synovial fluid.

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CLC: > Medicine, health > Chinese Medicine > Journal of Orthopaedics > Modern medicine, orthopedic diseases
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