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Clinical characteristics of traditional Chinese medical type of syndrome and prognosis analysis of chronic severe hepatitis B (CSHB) patientsObjective:Chronic severe hepatitis B is the main type of severe hepatitis in China, the incidence rate remains high. the complex syndrome, treatment is difficult, and poor prognosis. TCM syndrome differentiation is the main method of the diagnosis and treatment of diseases. This study aimed to reveal the distribution characteristics of syndromes, the basic clear with chronic severe hepatitis B TCM characteristics and distribution, improve the syndrome differentiation and treatment methods, the initial establishment of their own characteristics to adapt to the clinical efficacy evaluation system, in order to provide a basis for standardization of TCM syndrome differentiation.Methods:From January 2005 to December 2008 in Hubei Province Chinese Medicine Hospital,98 patients with chronic severe hepatitis B cases in retrospective surveys to collect medical information on the general information and four diagnostic information, laboratory test results were analyzed retrospectively, fill in the "chronic severe hepatitis B epidemiological survey on TCM Syndrome", the establishment of chronic severe hepatitis B retrospective study database. Using SPSS13.0, statistics software, the correlation of clinical data research and analysis, including the frequency distribution method, cluster analysis and Logistic regression, etc. of chronic severe hepatitis B syndrome laws.Results:1 According to frequency distribution method to get the chronic severe hepatitis B syndrome frequency distribution.2 Using the statistical software SPSS13.0 to 98 cases of chronic severe hepatitis b cluster analysis, cluster analysis results, according to expert opinion, combined TCM syndrome type slow fulminant can be divided into six types:the first class 1 characteristics of 27 patients for treating humid, The second type of pixu wet trapped for 23 cases, Article 3 for biaoben huanji qi and blood stasis eighteen cases, Article 4 for kidney deficiency of 13 patients, Article 5 of spleen and kidney Yang 11 patients, 6 class for hot ChiCheng poison of 6.3 TCM syndrome type and discusses the relationship between clinical stage one and 13 cases obtained in early September, medium, advanced in 5 cases, Spleen wet trapped in 2 cases, mid type early and late August 13, Qi and blood stasis biaoben huanji early middle type in 8 cases,7 cases,3 cases of late, Type 1 patients early kidney deficiency, middle and late August 4 cases. Spleen and kidney Yang 3 cases, mid early, late April 4 cases, Hot ChiCheng poison "in 0 case, mid early type 1,5 cases of late. Indicates that chronic fulminant hepatitis syndrome is accord with certain distribution law of development.4 Make an approach to the relationship between type and laboratory parameters derived indicators of humid yellow cards than the other three types of bilirubin increased significantly, indicating that damp heat evil easily lead to bilirubin metabolism. Huang Qi stasis permits albumin was markedly abnormal, indicating a poor prognosis serious condition. All card-type prothrombin time were extended, indicating a large number of patients with chronic severe hepatitis, liver cell necrosis, coagulation poor.5 TCM syndrome type and discusses the relationship between the evaluation of clinical curative effect, with TCM syndrome type by turns, clinical curative effect gradually becomes poor and is difficult to treat.6 Through the 2007-2008 67 cases of chronic fulminant hepatitis patient follow-up, and the statistics of TCM syndrome type rate between. Results showed that higher fatality kidney deficiency of liver and spleen different type mortality than wet trapped biaoben huanji qi and blood stasis syndrome type, every other no obvious difference between mortality.Conclusion:6type line with chronic severe hepatitis B clinical characteristics of TCM syndromes and rules of the basic pathogenesis of chronic severe hepatitis Immunotoxin for the damp heat of liver injury, liver failure caused by Shuxie, Qi stagnation blood stasis, muddy intrinsic toxicity, on the stem at the the brain, the next interference in the kidney, liver, leading to real corrupt body, forming actual situation mixed situation.Subject Words Severe hepatitis; Chronic; TCM symptoms; Prognosis
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