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The Synthesis and Characterization of the Biodegradable Drug-graft-polyester Elastomer

Author: SunChengWu
Tutor: SunZhiJie
School: Harbin Engineering University
Course: Materials Physics and Chemistry
Keywords: Carboxyl modified 5 - fluorouracil Curcumin Graft Drug release
CLC: TQ334.1
Type: Master's thesis
Year: 2011
Downloads: 11
Quote: 0
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Abstract


In this paper, chloroacetic a the carboxyl modified 5 - fluorouracil ( 5- FU ) synthesized under alkaline conditions , using infrared spectroscopy , nuclear magnetic resonance spectroscopy for structural characterization of modified drug . Use of sebacic acid and glycerin different ratio on the basis of doped with different concentrations of 5-Fu carboxyl-modified polyester elastomer melt polycondensation reaction method of synthesis , and sebacic acid and the proportion of glycerol based on doped with different concentrations curcumin polyester elastomer . By IR, NMR , X -ray diffraction , scanning electron microscopy , tensile , and high-performance liquid (HPLC) were characterized by their microstructure , mechanical properties and drug release behavior . Studies have shown that the structure of the modified 5-Fu containing carboxylic acid group, on the tumor cells have a significant cell inhibition . Carboxyl-modified 5 - FU can be successfully grafted glycerol esters of sebacic acid , curing the elastomer-forming , with the increase of the concentration of modified drug inside the polymer hydrogen weakened material decrease in hydrophilicity , the material cross-linking density decreases and then increases , the elastic modulus decreased , the material degradation weightlessness rate increase . The drug release of the elastic body is faster than the rate of release of the early , as the release time , the speed is gradually reduced, and six days later the speed is kept substantially constant , and as the modified drug concentration increases , the concentration of drug release over the same period is increased . Same concentration modified drug is incorporated , and sebacic acid , the proportion of glycerol is 1.2:1 compared to the elastomer , sebacic acid , glycerol ratio of 1.5:1 degree of crosslinking elastomer material modulus of elasticity volume larger , smaller degradation weight loss rate and the concentration of drug release . Curcumin successfully grafted glycerol esters of sebacic acid , curing the elastomer-forming polymer internal hydrogen enhanced with increasing curcumin concentration the material hydrophilic declines material crosslinking density decreases , the elastic The modulus decreased . The degradation of the curcumin - PGS elastomer weightlessness essentially linearly when curcumin incorporated in an amount up to 40 % , the degradation rate is the fastest . The drug release of the elastic body is faster than the rate of release of the early , four days after the speed starts to decrease and is maintained substantially constant , and the drug release rate during the same period has a tendency to increase with increasing curcumin concentration .

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CLC: > Industrial Technology > Chemical Industry > Rubber Industry > Thermoplastic elastomers > Polyester elastomer
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