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Study on the Synthetic Technology of o-Nitrophenylacetic Acid

Author: ShangGuanChunXuan
Tutor: WangJianLong
School: University of North
Course: Safety Technology and Engineering
Keywords: O-nitrophenyl acetate O-nitrotoluene Carboxylation Condensation oxidation
CLC: TQ245.27
Type: Master's thesis
Year: 2010
Downloads: 94
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Abstract


China's current rapid development of a nitrotoluene and its derivatives development , low prices , very competitive in the international arena . Nitrotoluene ( o-nitrotoluene nitrotoluene nitrotoluene = 60:4:36 ) synthesized by the nitration of toluene , the largest proportion of o-nitrotoluene nitrotoluene market demand , which resulted in excess production by the o-nitrotoluene . Nitrophenyl acetate organic intermediates , traditional synthetic methods of raw materials ( o-nitrophenyl acetonitrile) is not easy to get a wide range of uses . O-nitrotoluene study for the raw materials for the synthesis of o-nitrophenyl acetic acid process has a high practical value . In this thesis, the o-nitrotoluene in phenol sodium catalytic reaction with the carbon dioxide generated o-nitrophenyl acetate , o-nitrophenyl acetate after acidification and purification treatment . Meanwhile, the side effects that may occur . Condensation oxidation synthesis process , ethanol as solvent , sodium ethoxide catalyst process improvement measures and carried out preliminary exploration experiments . O-nitrotoluene with diethyl oxalate in the ethoxide catalyzed condensation, and then by hydrolysis, oxidation, and the solution was extracted , acidified to give o - nitrophenyl acetic acid . Come to its optimum synthesis conditions by orthogonal test : o-nitrotoluene , ethanol , sodium diethyl oxalate molar ratio for 1:1.2:1.28 ; condensation reaction temperature of 45 ° C ; time 3h ; oxidative decarboxylation The reaction temperature is below 20 ℃ . And validation experiments , product yield reached 89.2% , 98.70% purity .

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CLC: > Industrial Technology > Chemical Industry > Basic Organic Chemistry Industry > The production of aromatic compounds > Aromatic carboxylic acids and their derivatives > Aromatic acid functional derivatives > Nitrogen - containing functional derivatives
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