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Gastrointestinal stromal tumors Application and Evaluation of NIH programs and Dog1, WISP-1 expression and significance

Author: ZuoShunHai
Tutor: WenBin
School: North Sichuan Medical College
Course: Human Anatomy and Embryology
Keywords: Gastrointestinal stromal tumors Dog1 WISP-1 Prognosis
CLC: R735
Type: Master's thesis
Year: 2010
Downloads: 49
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Abstract

Objective: To detect Dogl and WISP-1 in gastrointestinal stromal tumors (GIST) expression, and explore Dogl and WISP-1 in gastrointestinal stromal tumors diagnostic and prognostic significance; through the analysis of clinical and pathological features and U.S. National Institutes of Health (NIH) recommended risk stratification for survival in GIST patients, and to explore the biological behavior of GIST and NIH programs on the risk classification of primary GIST assessment of the limitations of performance. Methods: North Sichuan Medical College Affiliated Hospital 124 cases with complete clinical and pathological data of GIST, immunohistochemical methods Envision method to detect Dog1 and WISP-1 protein in 124 cases of GIST, expression, and with non-gastric intestinal stromal tumor control study; summarize the clinical and pathological features including age, mitotic count, tumor diameter, etc., apply the new NIH classification scheme for this group of patients for risk stratification, and analyzed statistically. Results: 124 cases of GIST Dogl positive expression rate of 96% (119/124), CD117 positive expression rate was 91.0% change (111/124), both in GIST, the expression level of difference was not statistically significant (P gt; 0.05); gastrointestinal stromal tumors and non-gastrointestinal stromal tumor Dog1 expression levels were significantly (P lt; 0.001); This group of cases WISP-1 positive rate of 80.6% (100/124 ), which is very low risk, low risk, moderate risk, high risk, the positive expression rate was 44.4% (4/9), 66.7% (26/39), 86.9% (17/20), 95.0% (38/40), the number of patients with positive expression of NIH risk classification was positively correlated (P lt; 0.001); gastrointestinal stromal tumors and non-gastrointestinal stromal tumor WISP-1 expression levels showed no statistical significance (P gt; 0.05). 124 cases, 13 cases of GIST progressive (malignant) GIST, 111 cases of primary limitations of GIST, mean age 57 years; 82 cases were followed up, including progressive GIST9 cases, primary limitations GIST73 case. 73 cases with follow-up data of primary limitations of GIST patients, the tumor diameter greater than 5 cm (P = 0.009), mitotic count of more than 5 / 50HPF (P lt; 0.001) Tip survival rate; tumors same size (in 5.1 ~ 10.0 cm range), non-gastric GIST than gastric GIST disease-free survival rate (P = 0.011); onset age and sex has nothing to do with survival; This set of data according to the new NIH classification scheme to assess overall survival risk group and disease-free survival rate was significantly lower than very low, low, and moderate-risk group (P lt; 0.05), but very low, low, moderate risk between the three groups overall survival and disease-free survival difference was not statistically significant. Conclusion: Dogl gastrointestinal stromal tumors a sensitive and specific marker CD117 associated with the use of GIST can improve diagnostic accuracy, can be used as identification of mesenchymal tumors of the digestive tract frontline antibody used clinically; WISP- 1 expression may be related to the process of malignant GIST, may be used as indicators of the biological behavior of GIST assessment; according to tumor size, mitotic count and the incidence of part of the assessment of the degree of risk GIST NIH classification scheme to more accurately understand the limitations of primary GIST biological behavior; pathological diagnosis of GIST, the judge noted NIH classification in favor of GIST prognosis and guide the clinical treatment of GIST.

Gastrointestinal stromal tumors Application and Evaluation of NIH programs and Dog1, WISP-1 expression and significance

Abstract

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