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Objective To investigate the different indexing standards pregnant women, abnormal liver function intrahepatic cholestasis of pregnancy (ICP) , umbilical cord blood bile acid spectrum and pregnancy outcomes . The method of high performance liquid chromatography ICP cord blood bile acid spectrum , including tauro ursodeoxycholic acid ( TUDCA ) , taurocholic acid (TCA), glycocholate (GCA), glycyl lithocholic acid (GLCA), the taurocholic CDCA (TCDCA), taurocholic deoxycholic acid (TDCA), the glycyl CDCA (GCDCA), glycyl deoxycholic acid (GDCA). Using four ICP indexing method to compare ICP pregnant women liver function indicators , cord blood bile acid spectrum and pregnancy outcomes . Results (1) normal pregnancy and mild ICP group compared with standard three standard four- ALT , were statistically significant ( P lt; 0.05 ) AST , TBIL DBIL , differences in the four indexing standards Cord Blood Lines ( TCA ) GCA differences were statistically significant (P lt; 0.05), the standard one and standard two cord blood GLCA difference was statistically significant ( P lt; 0.05 ) the standard four cord blood GCDCA differences was statistically significant ( P lt; 0.05 ) standard three premature children the difference was statistically significant ( P lt; 0.05 ) . ( 2 ) normal pregnancy group and severe ICP group , the four indexing standards ALT , AST , TBIL, DBIL differences were statistically significant (P lt; 0.05), four standard cord blood TCA , GCA, GLCA TCDCA differences were statistically significant (P lt; 0.05), the standard , the standard two , standard four - cord blood GCDCA difference was statistically significant ( P lt; 0.05 ) , standard , Standard II standard four preterm children and meconium staining differences statistically significant ( P lt; 0.05 ) . ( 3 ) mild ICP group and severe ICP group compared to the standard one , standard ALT were statistically significant ( P lt; 0.05 ) AST , TBIL DBIL , differences in the four indexing standards Cord Blood Lines ( TCA ) , TCDCA difference was statistically significant (P lt; 0.05), the standard Cord Blood GCDCA difference was statistically significant ( P lt; 0.05 ) , the standard four - cord blood GLCA difference was statistically significant ( P lt; 0.05 ) , the standard Premature differences statistically significant ( P lt; 0.05 ) . Conclusion ICP indexing reflect different levels of the ICP pregnant women, abnormal liver function ; spectrum of ICP cord blood bile acid , the main component of tauro conjugated bile acid and glycyl- conjugated bile acids , tauro conjugated bile acid than glycyl -bound the high concentration of bile acids , the severe ICP cord blood TCA, TCDCA and GLCA are significantly higher than the the mild ICP and normal pregnancy ; severe ICP meconium staining , preterm children the incidence was significantly higher than the the mild ICP and normal pregnancy .
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