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Cardiovascular and cerebrovascular diseases, human health, \The disease will not only affect the lives of the patients and to the patients and their families, bring great harm to the community, or the cause of the heart, brain, kidney and other organ damage culprit. With the social development and the people's living standards improved, the incidence of coronary heart disease in the elderly population is increasing year by year, angina pectoris, myocardial infarction, seizures, but also a serious threat to the lives and safety of these patients. In recent years, with the continuous development of Chinese medicine formulations, pills in the application of Chinese medicine formulations more and more compelling, the dosage form has to be able to improve the bioavailability of insoluble drugs, easy to operate, less process, short cycle other prominent advantages the, Chuandan Futaba dripping pills can be better than a new Chinese medicine formulations of tablets, so we treat chest pain (angina pectoris, stroke) compound Chinese medicine preparation Chuandan double leaf drop pills developed carried out a systematic study. Determine Salvia extraction process: take Salvia medicinal crushed into a coarse powder, plus 10 times the amount of 95% ethanol extracted once 3h, filtration, combined filtrate, the filtrate was concentrated to dryness, and was extract. The alcohol extraction dregs plus 10 times the amount of water boiling water 2 times, each 90min, combined filtrate, and the filtrate was concentrated and dried using a freeze-drying, too dry powder. Chuanxiong extract: take Chuanxiong herbs pulverized into a coarse powder, plus a 12-fold amount of 80% ethanol for 1.5 hours, refluxed extracted 3 times every 2 h, filtered, the filtrates were combined, and the filtrate was concentrated and dried to give extract. Ginkgo biloba extract preparation process: the crushed leaves of the ginkgo extract twice with 50% ethanol, 50% ethanol dosages were eight times the amount of six times the amount of reflux time were 2 h, 1 h combined reflux extract was concentrated under reduced pressure to 1:1.5, add ethanol to 75% alcohol-containing supernatant was concentrated under reduced pressure to 1:4, plus 80% ethanol to the supernatant adjusted pH8.8 48 h after Lengchen, -9.0, centrifugal filtration. The filtrate was concentrated under reduced pressure to recover the ethanol, diluted with water to 6 times after adjusting pH6.8 to 7.0 with HCl. Take the same amount of D-101 resin and polyamide resin column packing, Ginkgo biloba extract solution by mixing column, after washing 10 times the amount of 70% ethanol desorption eluate was concentrated and dried products. Hawthorn leaf preparation process: crushed hawthorn leaves 60% ethanol extracted three times, each time 2 hours. Filtration, combined with the filtrate, and the filtrate was concentrated and dried to give extract. Orthogonal design a the dripping pills molding process, determine the process: take Salvia, Chuanxiong, ginkgo biloba, hawthorn leaf extract mixed ratio of 1:3 is added to the molten matrix (ratio of 1:1 PEG4000 and PEG6000 ) were mixed uniformly, under incubation of 85 ° C was poured into pill machine dropping distance of 5 cm of liquid paraffin was added dropwise condensing agent, cooling, curing into a pill. Preparations Drug Ginkgo biloba extract, Salvia miltiorrhiza, hawthorn leaves, chuanxiong were qualitative identification of the main active ingredient in Salvia Tanshinone Ⅱ A high-performance liquid chromatography using thin layer chromatography, the main active ingredients of ferulic acid in Chuanxiong Determination school visits, to develop quality standards. The effects of the initial stability of the formulations, results show that good preparation stability.
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