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Anti-tumor Study of the Fufang Wuguteng Capsule

Author: MuJuan
Tutor: GuoHuiLing
School: Shaanxi College of Traditional Chinese Medicine
Course: Of Pharmacy
Keywords: Compound black bone Capsule Antitumor Immunity
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 69
Quote: 0
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Abstract


Objective: This article is aimed at by the anti-tumor effect of compound black bone Capsule experimental study of its mechanism of action for entering clinical studies provide experimental basis. Methods: A mouse xenograft model observed the compound black bone Capsule on tumor-bearing mice bearing life-prolonging effect; its non-specific immunity, cellular immunity, humoral immunity and tumor-bearing mice, anti-fatigue hypoxia tolerance; chemoradiotherapy Reducing Toxicity. Results: The Compound black bone rattan capsule 2.25g/kg, 1.125g/kg, 0.5625g/kg, dose S180 mice three batches experimental average inhibition rate of 52.68%, 43.41% and 28.29% (P <0.01 ); average of three batches of experimental mice with Lewis lung tumor inhibition rate were 55.71%, 46.67% and 36.67% (P <0.01); S180 ascites tumor-bearing mice three batches of experiments the average life span of 26.06% 17.95%, 11.75%; This product 2.25g/kg, cytotoxic index 1.125g/kg dose group of mice with Lewis lung tumor necrosis factor (TNF) were 60.48% and 56.00% (P <0.01, P <0.05) ; This product 2.25g/kg 1.125g/kg the 0.5625g/kg dose group mice with Lewis lung natural killer (NK) cells, killing rate were 32.23%, 35.22%, 26.70% (P <0.01, P <0.05. ); This product 2.25g/kg, 1.125g/kg dose group significantly increase carbon clearance ability of S180 mice correction index was significantly higher than that of cyclophosphamide (CTX) group (P lt; 0.01); This product 2.25g/kg 1.125g/kg, 0.5625g/kg dose group and CTX group the hemolysin OD values ??were significant differences (P <0.01); This product 2.25g/kg dose group of S180 tumor swimming time of the mice, the survival time after acute hypoxia has a prolonged effect (P lt; 0.05); This product 2.25g/kg 1.125g/kg the 0.5625g/kg dose group 60Co irradiation in combination can significantly reduce radiotherapy mouse tumor weight (P lt; 0.05), which significantly higher radiation dose 2.25g/kg number of nucleated cells in the bone marrow of mice, the product of the number of CFU (P <0.05, P lt; 0.01); 1.125g/kg with CTX (20mg/kg) ,5-FU (20mg/kg) combined group average of two batches of experimental mice with Lewis lung tumor inhibition rate were 89.36% and 87.23% respectively, are greater than the combination of both medication After the theoretical additive effect value; This product 2.25g/kg, caused 1.125g/kg dose of CTX S180 mice bone marrow nucleated cells, peripheral blood leukocyte count decreased antagonistic role (P lt; 0.01 , P <0.05). Conclusion: The results show that the compound black bone Capsule has significantly inhibit tumor growth and prolong survival time, improve the tumor-bearing mice non-specific immunity, cellular immunity, humoral immune function, enhance its anti-fatigue, hypoxia tolerance, while The tumor-bearing mice with Synergy and Attenuation chemoradiotherapy.

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