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Fill yuan Congnao soup intervention of senile dementia rat behavior and hippocampal neuron apoptosis

Author: SunFangFang
Tutor: ChenMin
School: Liaoning University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: Senile dementia The complement elements Cong brain soup Behavior Hippocampal neurons Bcl-2 Bax Apoptosis
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 86
Quote: 0
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Abstract


Objective: The purpose of this paper is to explore senile dementia, kidney deficiency-based, The phlegm network underlying pathogenesis, and through the establishment of senile dementia rats composite model of multi-factor from behavioral and neuronal apoptosis in the hippocampus the angle of observation fill yuan Congnao soup intervention effect and mechanism of senile dementia. Methods: In this experimental ibotenic acid (IBO) β-amyloid 1-42 equal amount of compound injection method to copy AD rat model to complement the $ Congnao soup Chinese intervention, and set Western medicine piracetam (topiramate Levetiracetam tablets) for the control. Active and passive learning and memory in rats by Morris water maze test. Light microscope to observe pathological changes in hippocampus region. The Immunohistochemistry Determination hippocampus bax, bcl-2 protein expression levels. Results: 1. Behavior: the model group and the normal group escape latency was significantly longer, the number of cross-platform significantly reduced (P lt; 0.01); Chinese medicine group and western medicine group and the model group escape latency across platforms increased frequency ( P Apoptosis: the model group and the normal group, bax protein expression was significantly higher, bcl-2 were significantly decreased (P lt; 0.01); Chinese medicine group and western medicine group and the model group bax protein levels, bcl- 2 increased (P lt; 0.01). Chinese medicine group and western group, no significant difference (P gt; 0.05). Morphological changes: the number of neurons in the model group than the normal group was significantly reduced, the number of positive neurons was significantly increased and visible part of the nerve yuan nucleus pyknosis state, the nuclear membrane thickening, distortion, and even neuron degeneration and necrosis, cell lipofuscinosis factors, such as increased apoptosis. Chinese medicine group and western group are so positive neurons in the decrease in the number of regular distribution of nerve fibers compared with the model group. Conclusions: 1. Renal deficiency, phlegm and blood stasis senile dementia pathogenesis the kidney open stasis Ditan effective governance is. 2. Multifactorial composite model (IBO Aβ1-42) is capable of simulating the behavioral and pathological features of Alzheimer's disease, a reliable animal model. Complement of $ Congnao soup can significantly reduce AD ??hippocampal neurons in bax positive cells increased bcl-2 positive cells, inhibition of AD hippocampal neuronal apoptosis. 4. Fill yuan Congnao soup protection of the AD rat brain neurons by enhanced damage neurons in the hippocampus of bcl-2 protein expression and reduced the expression of bax protein. So as to improve learning and memory in AD rats.

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