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Heterocyclic Schiff Bases and Their Synthesis , Crystal Structure and Antibacterial Activity

Author: HuangDeHe
Tutor: YanLiuShui；LiuChongBo
School: Nanchang University of Aeronautics and
Course: Applied Chemistry
Keywords: Heterocyclic Schiff base Complex Crystal structure Antibacterial activity
CLC: O621.13
Type: Master's thesis
Year: 2010
Downloads: 316
Quote: 1
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Abstract


In recent years, heterocyclic Schiff base and its metal complexes due to their biological activity and pharmacological properties, such as antibacterial, anti-cancer, anti-inflammatory and anti-depressants, etc., more and more people's attention. Therefore, heterocyclic Schiff base ligand and its functional transition metal complexes in organic synthesis and study medicine and functional complex development and research has an important significance. To further enrich and broaden the heterocyclic Schiff base and its transition metal complexes, the paper on the basis of the previous work around drugs and functional complex organic design, synthesis and properties of synthesized seven new azacyclic and seven Schiff base complexes by X-ray diffraction analysis and other methods to characterize the structure of the compound, and these compounds and complexes of the antibacterial activity were studied. Paper is divided into four parts. A, introduces the Schiff base and its complexes synthesis and biological activity, on this basis, this paper presents the research objectives and programs. Second, the design and synthesis of seven heterocyclic Schiff bases: four kinds of PMBP Schiff bases, two kinds of single Schiff base, a double-Schiff base and an unsymmetrical Schiff base; three kinds of pyridine ring-containing Schiff base. By elemental analysis, infrared spectroscopy and X-ray single crystal diffraction compounds were characterized to determine its structure, and its crystal structure analysis. Third, o-formyl phenoxyacetic acid reduced isoniazid Schiff base as ligand, designed and synthesized seven kinds of transition metal complexes were characterized by elemental analysis, infrared spectroscopy and X-ray single crystal diffraction compounds were characterized to determine its structure and its crystal structure analysis. In these seven complexes, Co2, Ni2, Zn2 Rhu son were formed with a ligand complexes with two different structures, and Ag-ligand complexes formed undissociated carboxyl group, showcasing the richness of the ligand with bit mode. Fourth, the determination that has been synthesized Schiff base and Schiff base complexes on Escherichia coli, Staphylococcus aureus and Bacillus subtilis antimicrobial activity, the results show that they have some of the three strains inhibited the same concentration Next, PMBP shrink-phenylenediamine Schiff base bacteriostatic activity of the three generally better than PMBP shrink o-phenylenediamine, PMBP double reduction o-phenylenediamine Schiff Base Derived from PMBP antibacterial activity than o-phenylenediamine Schiff base, which is better than the N-2-PMBP-N'-cinnamic aldehyde - o-phenylenediamine Schiff base. The Schiff base of pyridine aldehydes in two Schiff bases strongest antibacterial activity, the maximum inhibition zone diameter of 2.83cm, while phthalates formyl phenoxyacetic acid reduced isoniazid Schiff base (H2L) complexes antibacterial activity than its ligands.

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Theory of organic chemistry,physical organic chemistry > Organic Chemistry Structure Theory
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