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Piperazine derivatives by the extensive attention has anti-bacterial , anti-hypertensive , anti-cancer , anti-inflammatory painkillers , anti-depressants and other biologically active . Containing piperazine derivatives drug research and development is extremely active, and have been a large number of drugs in the clinical application . The study found that the piperazine ring 1,4 - position different substituent groups may result in different biological activity . According to the pharmaceutically the principle of superposition , we will have a better biological activity of phosphorylating amino acid , the thiosemicarbazone and aroyl introduced into the structure of the piperazine to the filter obtained has a better biological activity of drug molecules . This article by two synthetic routes , respectively, after the five-step , and the six-step reaction , the synthesized piperazine 1,4 - bit aryl acyl and phosphoryl amino acids were substituted target compounds 10 and piperazine 1,4 - bits are condensing thiosemicarbazide and phosphoryl amino acids substituted target compounds 9 . All 19 target compounds have not been reported , and the four intermediate is no report of new compounds . All target compounds were confirmed by 1H NMR , 13C NMR , 31P NMR , IR , MS to confirm the structure . Also study some of these compounds with insulin , cytochrome C and lysozyme weak interaction , the most obvious results show that the role of these compounds and lysozyme . The synthetic route is as follows : Route 1 :
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