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Clinical Study on Treating Influenza of Biaohanlire Syndrome and the Role of Affecting IL-1、IL-6、TNF-a in Serum, with Chaiban Decoction

Author: JieLiuSong
Tutor: YuanChangJin
School: Hunan University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Influenza Cai plate soup IL-1 IL-6 TNF-a
CLC: R254
Type: Master's thesis
Year: 2010
Downloads: 64
Quote: 0
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Objective : To observe the treatment of influenza Cold in the efficacy of heat syndrome and IL -1 , IL -6 , TNF -a serum concentration levels of impact firewood plate soup . Methods: ① collect 79 cases of influenza patients were randomly divided into a treatment group of 40 cases , 39 cases of the control group . On the basis of the general treatment , the treatment group firewood plate soup for the investigational drug , the selection of the control group with Qingwen Capsule ( Hebei Yiling Pharmaceutical Group , R \u0026 D and production ) , are three days of a course of treatment ; ( 2 ) random sample (n = 20) patients and healthy subjects ( normal group ) 10 cases of serum by enzyme-linked immunosorbent assay (ELISA) detection of serum IL - 1 , IL -6 and TNF-a levels . Results: ( 1 ) in the treatment group efficiency is 95.0% , the the antipyretic average onset time of 3.30 hours . Control group was 76.9% , the the antipyretic average onset time of 4.89 hours . The efficacy of the treatment group compared with the control group significantly (P lt; 0.05). ( 2) the treatment group and the control group can effectively improve the main symptoms of influenza table cold heat syndrome patients and associated symptoms , and the efficacy of the treatment group for the main symptoms than the control group , the difference was statistically significant (P lt ; 0.05). ( 3 ) in the treatment group compared with the control group significantly reduced influenza serum cytokines IL - 1 , IL -6 and TNF-a content . Before treatment, of influenza serum IL - 1 , IL -6 and TNF-a water were higher than those in the normal group ( P lt; 0.05 ) , the difference was statistically significant . The two groups of influenza patients with serum IL - 1 , IL - 6 and TNF-a levels compared with before treatment (P lt; 0.05) , the difference was statistically significant . After treatment, serum IL -1 , IL - 6 and TNF-a level with the normal group comparison are P gt ; 0.05 , the difference was not statistically significant , the comparison with the normal group three concentration levels in the control group after treatment are P gt ; 0.05, no statistically significant difference . Conclusion : Description firewood plate soup clinically effective in the treatment of influenza , significantly reduce the serum of patients with influenza virus infection cytokines of IL-1 ( White mediated prime -1 ) of IL - 6 ( White mediated prime -6 ) and of TNF - a ( tumor necrosis factor -a) the content .

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