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Research on the Control of Solvent Loss in Lovastatin Manufacturing Process

Author: XuDi
Tutor: TanShiYu
School: Chongqing University
Course: Chemical Engineering and Technology
Keywords: Lovastatin production solvent loss control butyl acetate solvent extraction
CLC: TQ463
Type: Master's thesis
Year: 2011
Downloads: 40
Quote: 0
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Abstract


Lovastatin is used for regulating the blood lipid extensively, butyl acetate as extractant is widely used in the extraction process, and lots of butyl acetate lost. The loss of butyl acetate is not only potentially harmful for people’s health, but also puts great stress on environment, and causes serious economic losses.From the real lovastatin production of Chongqing XX company, this paper analyzed the ways and the reasons of the loss of butyl acetate, and proposed solutions respectively. Based on the original equipment installations, the solutions can control the solvent loss effectively. The temperature reduction and sealed operation were used in extraction and centrifugation processes, the countercurrent washing was used in washing process, and the wet distillation by adding water was used in distillation process, these applied solutions have controlled most of the steam loss of butyl acetate, and decreased the solvent loss in water from 190.3t/a to 63.4t/a.The recovery of butyl acetate from lovastatin wastewater was studied by using solvent extraction with liquid paraffin as the extractant. By single-factor tests, extraction time and phase ratio have great effects on the solvent extraction, while the effect of temperature and biomass content are slight. In optimum condition(15min, 25℃, 1:1 of phase ratio), the extraction efficiency can reach to 98 %. By multi-stage extraction, liquid paraffin shows a high loading ability, and the extraction efficiency in each run remains efficient within 10 stages. The loaded butyl acetate can be effectively recovered by vacuum evaporation. Moreover, the alkali treatment provides a successful way to regenerate the used LP, and the regenerated LP can be reused as many as 5 times without noticeable loss in extraction efficiency.The company will completely adopt the research-proposed loss control solutions in its new-built production line, by then, solvent loss in water will drop from 190.3t/a to less than 10t/a, and steam loss of solvent will be controlled totally. The application of these solutions provides a successful way to recover butyl acetate, which can cut the costs significantly. Besides, the application improves the environment of plant and surrounding region, which can remove the threats to staff and environment.

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug
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