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Coccidiostat to consider Synthesis of quinoline ester

Author: DiQingFeng
Tutor: WuFanHong；YangXueYan
School: East China University of Science and Technology
Course: Organic Chemistry
Keywords: Anticoccidial To consider quinoline ester Quinoline Synthesis
CLC: TQ453.2
Type: Master's thesis
Year: 2011
Downloads: 121
Quote: 0
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Abstract


This thesis is to test against coccidiosis quinoline ester synthesis was studied. Aniline as raw materials , diazotization , coupling, reduction, condensation , into the ether , ring closure to give the product a total of six steps to test quinoline ester , the total yield of 34.8% from the literature up to 51.6% . In the key intermediate 4 - hydroxy-5 - ethoxy- aniline , by reduction of the azo compound hydrosulfite method introduced amino group on the aromatic ring , not only three-step one-pot synthesis , and easily separated from the reduction product . Up to 95% crude purity , three steps in 86% yield , increased by 26.3% compared with the literature . Ground reference of the target product in the synthesis of quinoline ester intermediates may purified , the reaction directly . The condensation reaction is carried out without a solvent ; decyl alkylation catalyst by addition of water , strict control of the water content in the reaction system of 2% -5 % , the reaction rate can not only speed , but also increase the conversion rate, to avoid the costly catalyst or NaI use of KI . Three-step reaction overall yield of 60%. The intermediates are not purified synthetic route , and avoids the introduction of amino groups of the hydrogenation metal , reducing the post- processing and the intermediate use of organic solvents , is a test for mass production process of a new synthetic quinoline ester route.

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