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Objective: To retrospectively investigate the risk factors of affecting renal dysfun- ction in the hospitalized patients with chronic kidney disease, the conclusion could be used as a reference for the early prevention of chronic kidney disease.Methods: We reviewed the medical histories of 348 patients over 18 years with chronic kidney disease (not involving renal replacement therapy) hospitalized in our hospital from November 2009 to April 2010. We analysised the general run of things, primary disease, changing characteristics of some physiological and biochemical index- es. By the variation of the clinical parameters, we used multivariate regression model to explore risk factors of kidney dysfunction.Results:1. 348 cases were enrolled in the study, accounting for 17.82%, 7.18%, 15.23%, 32.18% and 27.59% from CKD stages 1 to 5. The average age in five stages showed the increased tendency.2. The most common causes of CKD were diabetes mellitus (36.49%), hypertension (29.60%) and primary glomerulonerphristis (18.68%) in the 348 cases.3. In addition to triglyceride, there was significant difference in each group with albumin, 24 hours volume of urinary protein, hemoglobin, total cholesterol, low density lipoprotein, high density lipoprotein, blood uric acid, blood calcium, serum inorganic phosphorus, intact parathyroid hormone, blood pressure and duration of disease (P<0.05). Compared with CKD stages 1 to 2, urinary protein quantity for 24 hours, blood uric acid, serum inorganic phosphorus, intact parathyroid hormone, systolic blood pressure and diastolic blood pressure in CKD stages 3 to 5 showed a higher level, however, total cholesterol, low density lipoprotein, high density lipoprotein and hemoglobin in CKD stages 3 to 5 showed a lower level (P<0.05). Besides, compared with CKD stages 1 to 2, albumin, blood calcium in CKD stages 4 to 5 showed a lower level (P<0.05).4. Multiple linear regression analysis showed that GFR was correlated positively with hemoglobin (P<0.05), while GFR was correlated negatively with age, urinary protein quantity for 24 hours, blood uric acid, systolic blood pressure and diastolic blood pressure (P<0.05). Furthermore, multiple logistic regression analysis showed that age, albuminuria, hypertension, hyperuricemia and anemia were the common risk factors for the progress of renal function of the chronic kidney disease (P<0.05).Conclusion:1.The most common causes of CKD was diabetes mellitus, hypertension, primary glomerulonerphristis.2. Age, albuminuria, anemia, hyperuricemia and hypertension were the common risk factors for the progress of renal function of the chronic kidney disease.
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